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The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain
المؤلفون المشاركون
Al-Saber, Feryal
Aldosari, Waleed
Alselaiti, Mariam
Khalfan, Hesham
Kaladari, Ahmed
Khan, Ghulam
Harb, George
Rehani, Riyadh
Kudo, Sizuka
Koda, Aya
Tanaka, Tohru
Nakajima, Motowo
Darwish, Abdulla
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Type 2 diabetes mellitus is prevalent especially in Gulf countries and poses serious long-term risks to patients.
A multifaceted treatment approach can include nutritional supplements with antioxidant properties such as 5-aminolevulinic acid (5-ALA) with sodium ferrous citrate (SFC).
This prospective, randomized, single-blind, placebo-controlled, dose escalating pilot clinical trial assessed the safety of 5-ALA with SFC at doses up to 200 mg 5-ALA/229.42 mg SFC per day in patients living in Bahrain with type 2 diabetes mellitus that was uncontrolled despite the use of one or more antidiabetic drugs.
Fifty-three patients (n=53) from 3 sites at one center were enrolled by Dr.
Feryal (Site #01), Dr.
Hesham (Site #02), and Dr.
Waleed (Site #03) (n=35, 5-ALA-SFC; n=18, placebo).
There was no significant difference in incidence of adverse events reported, and the most frequent events reported were gastrointestinal in nature, consistent with the known safety profile of 5-ALA in patients with diabetes.
No significant changes in laboratory values and no difference in hypoglycemia between patients receiving 5-ALA and placebo were noted.
Overall, the current results support that use of 5-ALA-SFC up to 200 mg per day taken as 2 divided doses is safe in patients taking concomitant oral antidiabetic medications and may offer benefits in the diabetic population.
This trial is registered with ClinicalTrials.gov NCT02481141.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Al-Saber, Feryal& Aldosari, Waleed& Alselaiti, Mariam& Khalfan, Hesham& Kaladari, Ahmed& Khan, Ghulam…[et al.]. 2016. The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108275
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Al-Saber, Feryal…[et al.]. The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108275
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Al-Saber, Feryal& Aldosari, Waleed& Alselaiti, Mariam& Khalfan, Hesham& Kaladari, Ahmed& Khan, Ghulam…[et al.]. The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108275
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108275
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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