Quercetin Isolated from Toona sinensis Leaves Attenuates Hyperglycemia and Protects Hepatocytes in High-CarbohydrateHigh-Fat Diet and Alloxan Induced Experimental Diabetic Mice
المؤلفون المشاركون
Zhang, Yali
Dong, Huanhuan
Wang, Mimi
Zhang, Jingfang
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The development of diabetes mellitus is related to oxidant stress induced by a high carbohydrate/high-fat diet (HFD).
Quercetin, as a major bioactive component in Toona sinensis leaves (QTL), is a natural antioxidant.
However, the exact mechanism by which QTL ameliorate diabetes mellitus is still unknown.
In this study, we investigated the hypoglycemic effects and hepatocytes protection of QTL on HFD and alloxan induced diabetic mice.
Intragastric administration of QTL significantly reduced body weight gain, serum glucose, insulin, total cholesterol, triglyceride, low density lipoprotein-cholesterol, alanine aminotransferase, and aspartate aminotransferase serum levels compared to those of diabetic mice.
Furthermore, it significantly attenuated oxidative stress, as determined by lipid peroxidation, nitric oxide content, and inducible nitric oxide synthase activity and as a result attenuated liver injury.
QTL also significantly suppressed the diabetes-induced activation of the p65/NF-κB and ERK1/2/MAPK pathways, as well as caspase-9 and caspase-3 levels in liver tissues of diabetic mice.
Finally, micrograph analysis of liver samples showed decreased cellular organelle injury in hepatocytes of QTL treated mice.
Taken together, QTL can be viewed as a promising dietary agent that can be used to reduce the risk of diabetes mellitus and its secondary complications by ameliorating oxidative stress in the liver.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yali& Dong, Huanhuan& Wang, Mimi& Zhang, Jingfang. 2016. Quercetin Isolated from Toona sinensis Leaves Attenuates Hyperglycemia and Protects Hepatocytes in High-CarbohydrateHigh-Fat Diet and Alloxan Induced Experimental Diabetic Mice. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108286
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yali…[et al.]. Quercetin Isolated from Toona sinensis Leaves Attenuates Hyperglycemia and Protects Hepatocytes in High-CarbohydrateHigh-Fat Diet and Alloxan Induced Experimental Diabetic Mice. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108286
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yali& Dong, Huanhuan& Wang, Mimi& Zhang, Jingfang. Quercetin Isolated from Toona sinensis Leaves Attenuates Hyperglycemia and Protects Hepatocytes in High-CarbohydrateHigh-Fat Diet and Alloxan Induced Experimental Diabetic Mice. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108286
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108286
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر