Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity
المؤلفون المشاركون
Jacobsen, Mette J.
Mentzel, Caroline M. Junker
Olesen, Ann Sofie
Huby, Thierry
Jørgensen, Claus B.
Barrès, Romain
Fredholm, Merete
Simar, David
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Obesity is associated with immunological perturbations that contribute to insulin resistance.
Epigenetic mechanisms can control immune functions and have been linked to metabolic complications, although their contribution to insulin resistance still remains unclear.
In this study, we investigated the link between metabolic dysfunction and immune alterations with the epigenetic signature in leukocytes in a porcine model of obesity.
Global DNA methylation of circulating leukocytes, adipose tissue leukocyte trafficking, and macrophage polarisation were established by flow cytometry.
Adipose tissue inflammation and metabolic function were further characterised by quantification of metabolites and expression levels of genes associated with obesity and inflammation.
Here we show that obese pigs showed bigger visceral fat pads, higher levels of circulating LDL cholesterol, and impaired glucose tolerance.
These changes coincided with impaired metabolism, sustained macrophages infiltration, and increased inflammation in the adipose tissue.
Those immune alterations were linked to global DNA hypermethylation in both B-cells and T-cells.
Our results provide novel insight into the possible contribution of immune cell epigenetics into the immunological disturbances observed in obesity.
The dramatic changes in the transcriptomic and epigenetic signature of circulating lymphocytes reinforce the concept that epigenetic processes participate in the increased immune cell activation and impaired metabolic functions in obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jacobsen, Mette J.& Mentzel, Caroline M. Junker& Olesen, Ann Sofie& Huby, Thierry& Jørgensen, Claus B.& Barrès, Romain…[et al.]. 2015. Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108287
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jacobsen, Mette J.…[et al.]. Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity. Journal of Diabetes Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108287
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jacobsen, Mette J.& Mentzel, Caroline M. Junker& Olesen, Ann Sofie& Huby, Thierry& Jørgensen, Claus B.& Barrès, Romain…[et al.]. Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108287
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108287
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر