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Experimental Diabetes Mellitus in Different Animal Models
المؤلفون المشاركون
Varga, Csaba
Murlasits, Zsolt
Veszelka, Médea
Török, Szilvia
Al-awar, Amin
Szűcs, Gergő
Attieh, Zouhair
Kupai, Krisztina
Pósa, Anikó
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-09
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Animal models have historically played a critical role in the exploration and characterization of disease pathophysiology and target identification and in the evaluation of novel therapeutic agents and treatments in vivo.
Diabetes mellitus disease, commonly known as diabetes, is a group of metabolic disorders characterized by high blood glucose levels for a prolonged time.
To avoid late complications of diabetes and related costs, primary prevention and early treatment are therefore necessary.
Due to its chronic symptoms, new treatment strategies need to be developed, because of the limited effectiveness of the current therapies.
We overviewed the pathophysiological features of diabetes in relation to its complications in type 1 and type 2 mice along with rat models, including Zucker Diabetic Fatty (ZDF) rats, BB rats, LEW 1AR1/-iddm rats, Goto-Kakizaki rats, chemically induced diabetic models, and Nonobese Diabetic mouse, and Akita mice model.
The advantages and disadvantages that these models comprise were also addressed in this review.
This paper briefly reviews the wide pathophysiological and molecular mechanisms associated with type 1 and type 2 diabetes, particularly focusing on the challenges associated with the evaluation and predictive validation of these models as ideal animal models for preclinical assessments and discovering new drugs and therapeutic agents for translational application in humans.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Al-awar, Amin& Kupai, Krisztina& Veszelka, Médea& Szűcs, Gergő& Attieh, Zouhair& Murlasits, Zsolt…[et al.]. 2016. Experimental Diabetes Mellitus in Different Animal Models. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108310
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Al-awar, Amin…[et al.]. Experimental Diabetes Mellitus in Different Animal Models. Journal of Diabetes Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108310
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Al-awar, Amin& Kupai, Krisztina& Veszelka, Médea& Szűcs, Gergő& Attieh, Zouhair& Murlasits, Zsolt…[et al.]. Experimental Diabetes Mellitus in Different Animal Models. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108310
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108310
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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