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Upregulation of α3β1-Integrin in Podocytes in Early-Stage Diabetic Nephropathy
المؤلفون المشاركون
Toyoda, Masao
Kaneyama, Noriko
Tanaka, Eitaro
Kimura, Moritsugu
Sawada, Kaichiro
Shiraiwa, Sawako
Moriya, Hitomi
Miyatake, Han
Yamamoto, Naoyuki
Miyauchi, Masaaki
Wada, Takehiko
Fukagawa, Masafumi
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Podocyte injury plays an important role in the onset and progression of diabetic nephropathy (DN).
Downregulation of α3β1-integrin expression in podocytes is thought to be associated with podocyte detachment from the glomerular basement membrane, although the mechanisms remain obscure.
To determine the mechanism of podocyte detachment, we analyzed the expression levels of α3β1-integrin in podocytes in early and advanced stages of DN.
Methods.
Surgical specimens from DN patients were examined by in situ hybridization, and the expression levels of α3- and β1-integrin subunits in glomeruli of early ( n = 6 ) and advanced ( n = 8 ) stages were compared with those of normal glomeruli ( n = 5 ).
Heat-sensitive mouse podocytes (HSMP) were cultured with TGF-β1 to reproduce the microenvironment of glomeruli of DN, and the expression levels of integrin subunits and the properties of migration and attachment were examined.
Results.
Podocytes of early-stage DN showed upregulation of α3- and β1-integrin expression while those of advanced stage showed downregulation.
Real-time PCR indicated a tendency for upregulation of α3- and β1-integrin in HSMP cultured with TGF-β1.
TGF-β1-stimulated HSMP also showed enhanced in vitro migration and attachment on collagen substrate.
Conclusions.
The results suggested that podocyte detachment during early stage of DN is mediated through upregulation of α3β1-integrin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sawada, Kaichiro& Toyoda, Masao& Kaneyama, Noriko& Shiraiwa, Sawako& Moriya, Hitomi& Miyatake, Han…[et al.]. 2016. Upregulation of α3β1-Integrin in Podocytes in Early-Stage Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108322
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sawada, Kaichiro…[et al.]. Upregulation of α3β1-Integrin in Podocytes in Early-Stage Diabetic Nephropathy. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108322
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sawada, Kaichiro& Toyoda, Masao& Kaneyama, Noriko& Shiraiwa, Sawako& Moriya, Hitomi& Miyatake, Han…[et al.]. Upregulation of α3β1-Integrin in Podocytes in Early-Stage Diabetic Nephropathy. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108322
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108322
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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