Higher Sensitivity and Earlier Identification of Celiac Disease Autoimmunity by a Nonradioactive Assay for Transglutaminase Autoantibodies
المؤلفون المشاركون
Rewers, Marian
Dong, Fran
Wang, Yuehui
Zhao, Zhiyuan
Miao, Dongmei
Waugh, Kathleen
Taki, Iman
Yu, Liping
Liu, Edwin
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-26
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Higher sensitive transglutaminase autoantibody (TGA) assay will detect the onset of celiac disease (CD) autoimmunity earlier.
In developing a nonradioactive assay for TGA, we utilized electrochemiluminescence (ECL) technology and compared it to a high-performance radioimmunoassay (RIA) currently being used to screen patients with type 1 diabetes (T1D) and genetically at-risk individuals for CD.
We selected 183 T1D patients with 60 patients having received biopsy and analyzed 396 sequential samples from 73 young children longitudinally followed up with TGA seroconversion, with 27 undergoing biopsy.
In addition, 112 age-matched healthy control subjects were included in the study.
With the 99th percentile of specificity, the ECL assay detected significantly more TGA positivity among patients with T1D (133/183) than RIA (114/183) and more of the sequential samples (34%) from 73 children than RIA (18%).
The TGA assay performed by ECL was positive in all 59 subjects with villous atrophy.
Among 73 longitudinally followed up children, ECL assay had earlier detection of TGA on 34 children by a mean of 2.5 years.
In conclusion, the new TGA assay by ECL has a higher sensitivity than the current RIA assay and may better predict the onset of CD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Zhiyuan& Miao, Dongmei& Waugh, Kathleen& Taki, Iman& Dong, Fran& Liu, Edwin…[et al.]. 2016. Higher Sensitivity and Earlier Identification of Celiac Disease Autoimmunity by a Nonradioactive Assay for Transglutaminase Autoantibodies. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1108747
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Zhiyuan…[et al.]. Higher Sensitivity and Earlier Identification of Celiac Disease Autoimmunity by a Nonradioactive Assay for Transglutaminase Autoantibodies. Journal of Immunology Research No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1108747
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Zhiyuan& Miao, Dongmei& Waugh, Kathleen& Taki, Iman& Dong, Fran& Liu, Edwin…[et al.]. Higher Sensitivity and Earlier Identification of Celiac Disease Autoimmunity by a Nonradioactive Assay for Transglutaminase Autoantibodies. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1108747
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108747
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر