Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis
المؤلفون المشاركون
Oral, H. Barbaros
Budak, Ferah
Bal, Salih Haldun
Tezcan, Gulcin
Akalın, Halis
Goral, Guher
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Brucellosis is a zoonotic disease that is still endemic in developing countries.
Despite early diagnosis and treatment of patients, chronic infections are seen in 10–30% of patients.
In this study, we aimed to investigate the immunological factors that play roles in the transition of brucellosis from acute infection into chronic infection.
Here, more than 2000 miRNAs were screened in peripheral blood mononuclear cells (PBMCs) of patients with acute or chronic brucellosis and healthy controls by using miRNA array, and the results of the miRNA array were validated through qRT-PCR.
Findings were evaluated using GeneSpring GX (Agilent) 13.0 software and KEGG pathway analysis.
Four miRNAs were expressed in the chronic group but were not expressed in acute and control groups.
Among these miRNAs, the expression level of miR-1238-3p was increased while miR-494, miR-6069, and miR-139-3p were decreased ( p < 0.05 , fold change > 2).
These miRNAs have the potential to be markers for chronic cases.
The differentially expressed miRNAs and their predicted target genes involved in endocytosis, regulation of actin cytoskeleton, MAPK signaling pathway, and cytokine-cytokine receptor interaction and its chemokine signaling pathway indicate their potential roles in chronic brucellosis and its progression.
It is the first study of miRNA expression analysis of human PBMC to clarify the mechanism of inveteracy in brucellosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Budak, Ferah& Bal, Salih Haldun& Tezcan, Gulcin& Akalın, Halis& Goral, Guher& Oral, H. Barbaros. 2016. Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108792
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Budak, Ferah…[et al.]. Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis. Journal of Immunology Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108792
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Budak, Ferah& Bal, Salih Haldun& Tezcan, Gulcin& Akalın, Halis& Goral, Guher& Oral, H. Barbaros. Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108792
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108792
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر