![](/images/graphics-bg.png)
Monocyte Activation in Immunopathology: Cellular Test for Development of Diagnostics and Therapy
المؤلفون المشاركون
Ivanova, Ekaterina A.
Orekhov, Alexander N.
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Several highly prevalent human diseases are associated with immunopathology.
Alterations in the immune system are found in such life-threatening disorders as cancer and atherosclerosis.
Monocyte activation followed by macrophage polarization is an important step in normal immune response to pathogens and other relevant stimuli.
Depending on the nature of the activation signal, macrophages can acquire pro- or anti-inflammatory phenotypes that are characterized by the expression of distinct patterns of secreted cytokines and surface antigens.
This process is disturbed in immunopathologies resulting in abnormal monocyte activation and/or bias of macrophage polarization towards one or the other phenotype.
Such alterations could be used as important diagnostic markers and also as possible targets for the development of immunomodulating therapy.
Recently developed cellular tests are designed to analyze the phenotype and activity of living cells circulating in patient’s bloodstream.
Monocyte/macrophage activation test is a successful example of cellular test relevant for atherosclerosis and oncopathology.
This test demonstrated changes in macrophage activation in subclinical atherosclerosis and breast cancer and could also be used for screening a panel of natural agents with immunomodulatory activity.
Further development of cellular tests will allow broadening the scope of their clinical implication.
Such tests may become useful tools for drug research and therapy optimization.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ivanova, Ekaterina A.& Orekhov, Alexander N.. 2016. Monocyte Activation in Immunopathology: Cellular Test for Development of Diagnostics and Therapy. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108798
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ivanova, Ekaterina A.& Orekhov, Alexander N.. Monocyte Activation in Immunopathology: Cellular Test for Development of Diagnostics and Therapy. Journal of Immunology Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108798
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ivanova, Ekaterina A.& Orekhov, Alexander N.. Monocyte Activation in Immunopathology: Cellular Test for Development of Diagnostics and Therapy. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108798
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108798
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)