Monocyte Differentiation towards Protumor Activity Does Not Correlate with M1 or M2 Phenotypes
المؤلفون المشاركون
Arriaga-Pizano, Lourdes
Espinoza-Sánchez, N. A.
Chimal-Ramírez, G. K.
Chávez-Sánchez, Luis
Fuentes-Pananá, Ezequiel M.
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-08
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Macrophages facilitate breast cancer progression.
Macrophages were initially classified as M1 or M2 based on their distinct metabolic programs and then expanded to include antitumoral (M1) and protumoral (M2) activities.
However, it is still uncertain what markers define the pro- and antitumoral phenotypes and what conditions lead to their formation.
In this study, monocytic cell lines and primary monocytes were subjected to commonly reported protocols of M1/M2 polarization and conditions known to engage monocytes into protumoral functions.
The results showed that only IDO enzyme and CD86 M1 markers were upregulated correlating with M1 polarization.
TNF-α, CCR7, IL-10, arginase I, CD36, and CD163 were expressed indistinguishably from M1 or M2 polarization.
Similarly, protumoral engaging resulted in upregulation of both M1 and M2 markers, with conditioned media from the most aggressive breast cancer cell line promoting the greatest changes.
In spite of the mixed phenotype, M1-polarized macrophages exhibited the highest expression/secretion of inflammatory mediators, many of which have previously been associated with breast cancer aggressiveness.
These data argue that although the existence of protumoral macrophages is unquestionable, their associated phenotypes and the precise conditions driving their formation are still unclear, and those conditions may need both M1 and M2 stimuli.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chimal-Ramírez, G. K.& Espinoza-Sánchez, N. A.& Chávez-Sánchez, Luis& Arriaga-Pizano, Lourdes& Fuentes-Pananá, Ezequiel M.. 2016. Monocyte Differentiation towards Protumor Activity Does Not Correlate with M1 or M2 Phenotypes. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1108837
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chimal-Ramírez, G. K.…[et al.]. Monocyte Differentiation towards Protumor Activity Does Not Correlate with M1 or M2 Phenotypes. Journal of Immunology Research No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1108837
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chimal-Ramírez, G. K.& Espinoza-Sánchez, N. A.& Chávez-Sánchez, Luis& Arriaga-Pizano, Lourdes& Fuentes-Pananá, Ezequiel M.. Monocyte Differentiation towards Protumor Activity Does Not Correlate with M1 or M2 Phenotypes. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1108837
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108837
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر