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Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy
المؤلفون المشاركون
Jiang, Yanfang
Zhang, Nan
Zhang, Li
Zhang, Zhihui
Wang, Haifeng
Crew, Rebecca
Liu, Xiaolei
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-09
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
The IL-33/ST2 axis is involved in humoral immune responses.
Method.
The concentrations of sera IL-33 and sST2 in 74 patients and 34 healthy controls (HC) were measured by ELISA.
Clinical and laboratory data were examined.
The potential association between sera IL-33 and sST2 and the clinical parameters in IgAN patients were analyzed.
Results.
No difference was discovered in IL-33 concentrations between IgAN patients and HCs; however, the sST2 were significantly higher in each stage of IgAN progression than in the HC.
The concentration of sST2 was positively correlated with IL-33 levels in IgAN patients.
Higher levels of sera IL-2, IL-4, IL-10, IL-17A, and IFN-γ were detected in patients compared to the HC.
The concentration of serum sST2 was positively correlated with the levels of IL-10 in IgAN patients.
Furthermore, serum sST2 was negatively correlated with the values of eGFR and serum calcium.
Serum sST2 was positively correlated with 24-hour urinary protein, serum phosphorus, and serum IgA; however, serum IL-33 was not associated with these.
Following treatment, serum sST2 was significantly decreased, while sera IL-4 and IL-10 were significantly increased.
Conclusions.
Increased sST2 and IL-10 but not IL-33 may be involved in the pathogenic process of IgAN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Zhihui& Wang, Haifeng& Zhang, Li& Crew, Rebecca& Zhang, Nan& Liu, Xiaolei…[et al.]. 2016. Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108850
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Zhihui…[et al.]. Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy. Journal of Immunology Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108850
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Zhihui& Wang, Haifeng& Zhang, Li& Crew, Rebecca& Zhang, Nan& Liu, Xiaolei…[et al.]. Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108850
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108850
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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