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In Vivo Chemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil
المؤلفون المشاركون
Prado-Garcia, Heriberto
Rodríguez-Padilla, Cristina
Coronado-Cerda, Erika Evangelina
Franco-Molina, Moisés Armides
Mendoza-Gamboa, Edgar
Rivera-Morales, Lydia Guadalupe
Zapata-Benavides, Pablo
Rodríguez-Salazar, María del Carmen
Caballero-Hernandez, Diana
Tamez-Guerra, Reyes Silvestre
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Chemotherapy treatments induce a number of side effects, such as leukopenia neutropenia, peripheral erythropenia, and thrombocytopenia, affecting the quality of life for cancer patients.
5-Fluorouracil (5-FU) is wieldy used as myeloablative model in mice.
The bovine dialyzable leukocyte extract (bDLE) or IMMUNEPOTENT CRP® (ICRP) is an immunomodulatory compound that has antioxidants and anti-inflammatory effects.
In order to investigate the chemoprotection effect of ICRP on bone marrow cells in 5-FU treated mice, total bone marrow (BM) cell count, bone marrow colony forming units-granulocyte/macrophage (CFU-GM), cell cycle, immunophenotypification, ROS/superoxide and Nrf2 by flow cytometry, and histological and hematological analyses were performed.
Our results demonstrated that ICRP increased BM cell count and CFU-GM number, arrested BM cells in G0/G1 phase, increased the percentage of leukocyte, granulocytic, and erythroid populations, reduced ROS/superoxide formation and Nrf2 activation, and also improved hematological levels and weight gain in 5-FU treated mice.
These results suggest that ICRP has a chemoprotective effect against 5-FU in BM cells that can be used in cancer patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Coronado-Cerda, Erika Evangelina& Franco-Molina, Moisés Armides& Mendoza-Gamboa, Edgar& Prado-Garcia, Heriberto& Rivera-Morales, Lydia Guadalupe& Zapata-Benavides, Pablo…[et al.]. 2016. In Vivo Chemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108861
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Coronado-Cerda, Erika Evangelina…[et al.]. In Vivo Chemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil. Journal of Immunology Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108861
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Coronado-Cerda, Erika Evangelina& Franco-Molina, Moisés Armides& Mendoza-Gamboa, Edgar& Prado-Garcia, Heriberto& Rivera-Morales, Lydia Guadalupe& Zapata-Benavides, Pablo…[et al.]. In Vivo Chemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108861
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108861
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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