Function of G-Protein-Coupled Estrogen Receptor-1 in Reproductive System Tumors

المؤلفون المشاركون

Shi, Guixiu
Qian, Hongyan
Xuan, Jingxiu
Liu, Yuan

المصدر

Journal of Immunology Research

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-05-29

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الأحياء

الملخص EN

The G-protein-coupled estrogen receptor-1 (GPER-1), also known as GPR30, is a novel estrogen receptor mediating estrogen receptor signaling in multiple cell types.

The progress of estrogen-related cancer is promoted by GPER-1 activation through mitogen-activated protein kinases (MAPK), phosphoinositide 3-kinase (PI3K), and phospholipase C (PLC) signaling pathways.

However, this promoting effect of GPER-1 is nonclassic estrogen receptor (ER) dependent manner.

In addition, clinical evidences revealed that GPER-1 is associated with estrogen resistance in estrogen-related cancer patients.

These give a hint that GPER-1 may be a novel therapeutic target for the estrogen-related cancers.

However, preclinical studies also found that GPER-1 activation of its special agonist G-1 inhibits cancer cell proliferation.

This review aims to summarize the characteristics and complex functions of GPER-1 in cancers.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Qian, Hongyan& Xuan, Jingxiu& Liu, Yuan& Shi, Guixiu. 2016. Function of G-Protein-Coupled Estrogen Receptor-1 in Reproductive System Tumors. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108864

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Qian, Hongyan…[et al.]. Function of G-Protein-Coupled Estrogen Receptor-1 in Reproductive System Tumors. Journal of Immunology Research No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1108864

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Qian, Hongyan& Xuan, Jingxiu& Liu, Yuan& Shi, Guixiu. Function of G-Protein-Coupled Estrogen Receptor-1 in Reproductive System Tumors. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108864

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1108864