Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis
المؤلفون المشاركون
Wang, Ying
Wang, Lili
Yang, Haoyu
Yuan, Weichang
Ren, Jingyi
Bai, Yanping
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-28
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated.
Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis.
The frequency and function of cTfh cells were compared between patients with psoriasis vulgaris and healthy controls, and the infiltration of Tfh cells was detected between lesional and nonlesional skin tissues of psoriasis patients.
Moreover, the dynamic change of cTfh cells before and after acitretin treatment was evaluated.
Our results showed both increased frequency and activation (indicated by higher expression of ICOS, PD-1, HLA-DR, and Ki-67 and increased production of IL-21, IL-17, and IFN-γ) of cTfh cells in psoriasis patients.
Compared with nonlesional skin tissues of psoriasis patients, the number of infiltrated Tfh cells was significantly increased in psoriasis lesions.
In addition, positive correlations between the percentage of cTfh, functional markers on cTfh cells in peripheral blood and disease severity were noted.
Furthermore, the frequency of cTfh cells and the levels of cytokines secreted by cTfh cells were all significantly decreased after 1-month treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ying& Wang, Lili& Yang, Haoyu& Yuan, Weichang& Ren, Jingyi& Bai, Yanping. 2016. Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108868
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ying…[et al.]. Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis. Journal of Immunology Research No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1108868
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ying& Wang, Lili& Yang, Haoyu& Yuan, Weichang& Ren, Jingyi& Bai, Yanping. Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108868
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108868
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر