The Effect of Histological CD20-Positive B Cell Infiltration in Acute Cellular Rejection on Kidney Transplant Allograft Survival
المؤلفون المشاركون
Chen, Jianghua
Jiang, Yan
Wang, Rending
Wang, Huiping
Huang, Hongfeng
Peng, Wenhan
Qiu, Wenxian
Zhou, Jingyi
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
It is controversial whether lymphocyte infiltration exhibited in biopsy specimens is associated with transplant outcomes.
This study focused on the effect of CD20-positive B cell infiltration in biopsy specimens from allografts with acute cellular rejection (ACR) in a Chinese population.
Methods.
Altogether, 216 patients transplanted from Sep.
2001 to Dec.
2014 with biopsy-proved ACR (Banff I or Banff II) were included in the analysis.
Biopsies were immunostained for CD20 and C4d.
Baseline information, serum creatinine and GFR before and after treatment, steroid resistance, response to treatment, graft loss, and survival were analyzed.
Results.
Eighty-three patients were classified into CD20-negative group, and 133 patients were classified into CD20-positive group.
Significantly more CD20-negative patients (49/83, 59.0%) received steroid plus antibody therapy compared with the CD20-positive group (52/133, 39.1%) (P=0.004).
The response to treatment for ACR did not differ between these two groups.
The CD20-positive group had less graft loss (18.8% versus 32.5%, P=0.022) and a better graft survival rate.
Further exploration of the infiltration degree suggested that it tended to be positively related to graft survival, but this did not reach statistical significance.
Conclusion.
CD20-positive B cell infiltration in renal allograft biopsies with ACR is associated with less steroid resistance and better graft survival.
The presence of CD20-positive B cells is protective for renal allografts.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Yan& Wang, Rending& Wang, Huiping& Huang, Hongfeng& Peng, Wenhan& Qiu, Wenxian…[et al.]. 2016. The Effect of Histological CD20-Positive B Cell Infiltration in Acute Cellular Rejection on Kidney Transplant Allograft Survival. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108873
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Yan…[et al.]. The Effect of Histological CD20-Positive B Cell Infiltration in Acute Cellular Rejection on Kidney Transplant Allograft Survival. Journal of Immunology Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108873
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Yan& Wang, Rending& Wang, Huiping& Huang, Hongfeng& Peng, Wenhan& Qiu, Wenxian…[et al.]. The Effect of Histological CD20-Positive B Cell Infiltration in Acute Cellular Rejection on Kidney Transplant Allograft Survival. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108873
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108873
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر