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Effect of N-Feruloylserotonin and Methotrexate on Severity of Experimental Arthritis and on Messenger RNA Expression of Key Proinflammatory Markers in Liver
المؤلفون المشاركون
Pašková, Ľudmila
Kuncírová, Viera
Poništ, Silvester
Mihálová, Danica
Harmatha, Juraj
Hrádková, Iveta
Čavojský, Tomáš
Bilka, František
Šišková, Katarína
Paulíková, Ingrid
Bezáková, Lýdia
Bauerová, Katarína
Nosál’, Radomír
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Rheumatoid arthritis (RA) is a chronic inflammatory disease, leading to progressive destruction of joints and extra-articular tissues, including organs such as liver and spleen.
The purpose of this study was to compare the effects of a potential immunomodulator, natural polyphenol N-feruloylserotonin (N-f-5HT), with methotrexate (MTX), the standard in RA therapy, in the chronic phase of adjuvant-induced arthritis (AA) in male Lewis rats.
The experiment included healthy controls (CO), arthritic animals (AA), AA given N-f-5HT (AA-N-f-5HT), and AA given MTX (AA-MTX).
N-f-5HT did not affect the body weight change and clinical parameters until the 14th experimental day.
Its positive effect was rising during the 28-day experiment, indicating a delayed onset of N-f-5HT action.
Administration of either N-f-5HT or MTX caused reduction of inflammation measured as the level of CRP in plasma and the activity of LOX in the liver.
mRNA transcription of TNF-α and iNOS in the liver was significantly attenuated in both MTX and N-f-5HT treated groups of arthritic rats.
Interestingly, in contrast to MTX, N-f-5HT significantly lowered the level of IL-1β in plasma and IL-1β mRNA expression in the liver and spleen of arthritic rats.
This speaks for future investigations of N-f-5HT as an agent in the treatment of RA in combination therapy with MTX.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pašková, Ľudmila& Kuncírová, Viera& Poništ, Silvester& Mihálová, Danica& Nosál’, Radomír& Harmatha, Juraj…[et al.]. 2016. Effect of N-Feruloylserotonin and Methotrexate on Severity of Experimental Arthritis and on Messenger RNA Expression of Key Proinflammatory Markers in Liver. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108875
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pašková, Ľudmila…[et al.]. Effect of N-Feruloylserotonin and Methotrexate on Severity of Experimental Arthritis and on Messenger RNA Expression of Key Proinflammatory Markers in Liver. Journal of Immunology Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108875
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pašková, Ľudmila& Kuncírová, Viera& Poništ, Silvester& Mihálová, Danica& Nosál’, Radomír& Harmatha, Juraj…[et al.]. Effect of N-Feruloylserotonin and Methotrexate on Severity of Experimental Arthritis and on Messenger RNA Expression of Key Proinflammatory Markers in Liver. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108875
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108875
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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