Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection
المؤلفون المشاركون
Carvalho, Edgar M.
Lima, Clara Mônica
Dourado, Adriana
Carvalho, Natália B.
Bittencourt, Valéria
Lessa, Marcus Miranda
Siqueira, Isadora
Santos, Silvane
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-19
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The Sjögren syndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers.
However the diagnosis of Sjögren syndrome in these subjects has been contested.
In this cross-sectional study, we evaluated the role of immunological factors and proviral load, in sicca syndrome associated with HTLV-1 in patients without myelopathy.
Subjects were recruited in the HTLV-1 Clinic, from 2009 to 2011.
The proviral load and cytokine levels (IFN-γ, TNF-α, IL-5, and IL-10) were obtained from a database containing the values presented by the subjects at admission in the clinic.
Of the 272 participants, 59 (21.7%) had sicca syndrome and in all of them anti-Sjögren syndrome related antigen A (SSA) and antigen B (SSB) were negatives.
The production of TNF-α and IFN-γ was higher in the group with sicca syndrome ( P < 0.05 ) than in HTLV-1 infected subjects without sicca syndrome.
Our data indicates that patients with sicca syndrome associated with HTLV-1 do not have Sjögren syndrome.
However the increased production of TNF-α and IFN-γ in this group of patients may contribute to the pathogenesis of sicca syndrome associated with HTLV-1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lima, Clara Mônica& Santos, Silvane& Dourado, Adriana& Carvalho, Natália B.& Bittencourt, Valéria& Lessa, Marcus Miranda…[et al.]. 2016. Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108894
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lima, Clara Mônica…[et al.]. Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection. Journal of Immunology Research No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1108894
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lima, Clara Mônica& Santos, Silvane& Dourado, Adriana& Carvalho, Natália B.& Bittencourt, Valéria& Lessa, Marcus Miranda…[et al.]. Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108894
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108894
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر