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Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases
المؤلفون المشاركون
Yang, Jiali
Chi, Shuhong
Shi, Juan
Xue, Jing
Li, Feng
Liu, Xiaoming
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-27
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
The Wnt signaling pathway plays a key role in many biological aspects, such as cellular proliferation, tissue regeneration, embryonic development, and other systemic effects.
Under a physiological condition, it is tightly controlled at different layers and arrays, and a dysregulated activation of this signaling has been implicated into the pathogenesis of various human disorders, including autoimmune diseases.
Despite the fact that therapeutic interventions are available for ameliorating disease manifestations, there is no curative therapy currently available for autoimmune disorders.
Increasing lines of evidence have suggested a crucial role of Wnt signaling during the pathogenesis of many autoimmune diseases; in addition, some of microRNAs (miRNAs), a class of small, noncoding RNA molecules capable of transcriptionally regulating gene expression, have also recently been demonstrated to possess both physiological and pathological roles in autoimmune diseases by regulating the Wnt signaling pathway.
This review summarizes currently our understanding of the pathogenic roles of Wnt signaling in several major autoimmune disorders and miRNAs, those targeting Wnt signaling in autoimmune diseases, with a focus on the implication of the Wnt signaling as potential biomarkers and therapeutic targets in immune diseases, as well as miRNA-mediated regulation of Wnt signaling activation in the development of autoimmune diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Juan& Chi, Shuhong& Xue, Jing& Yang, Jiali& Li, Feng& Liu, Xiaoming. 2016. Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1108918
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Juan…[et al.]. Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases. Journal of Immunology Research No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1108918
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Juan& Chi, Shuhong& Xue, Jing& Yang, Jiali& Li, Feng& Liu, Xiaoming. Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1108918
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108918
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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