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Gold Nanoparticles Promote Proliferation of Human Periodontal Ligament Stem Cells and Have Limited Effects on Cells Differentiation
المؤلفون المشاركون
Li, Chen
Li, Zhuoquan
Wang, Yan
Liu, Hongwei
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Gold nanoparticles (AuNPs) had been widely applied in the practice and advancement of chemistry, biology, and medicine due to facility of synthesis and versatility in surface functionalization.
Recent studies had shown that AuNPs can be applied to cells, affecting cellular physiological processes such as proliferation and differentiation.
In this study, four diameters of AuNPs (20, 40, 60, and 80 nm) were cocultured with human periodontal ligament cells (hPDLCs) at six different concentrations.
The optimal size and concentration of AuNPs were selected to treat human periodontal ligament stem cells (hPDLSCs) to evaluate proliferation.
Moreover, the influence of AuNPs on multiple differentiation capacity of hPDLSCs was clarified.
The results revealed that AuNPs (60 nm, 56 μM) can effectively promote the proliferation of hPDLCs/hPDLSCs in vitro, slightly enhance osteoblastic differentiation, and have no effect on adipogenic differentiation.
In addition, the expression of COL-1, Runx2, BSP, and OCN was upregulated in the presence of AuNPs (60 nm, 56 μM).
These results indicated that AuNPs (60 nm, 56 μM) can effectively promote the proliferation of hPDLCs/hPDLSCs and have no significant effect on the differentiation of hPDLSCs.
These results provide an insight on the advantage of implementing of AuNPs on hPDLSCs culture and expose the influence of these materials on periodontal tissue engineering.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Chen& Li, Zhuoquan& Wang, Yan& Liu, Hongwei. 2016. Gold Nanoparticles Promote Proliferation of Human Periodontal Ligament Stem Cells and Have Limited Effects on Cells Differentiation. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109008
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Chen…[et al.]. Gold Nanoparticles Promote Proliferation of Human Periodontal Ligament Stem Cells and Have Limited Effects on Cells Differentiation. Journal of Nanomaterials No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1109008
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Chen& Li, Zhuoquan& Wang, Yan& Liu, Hongwei. Gold Nanoparticles Promote Proliferation of Human Periodontal Ligament Stem Cells and Have Limited Effects on Cells Differentiation. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109008
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109008
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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