Development of a Doxycycline Hydrochloride-Loaded Electrospun Nanofibrous Membrane for GTRGBR Applications
المؤلفون المشاركون
Jia, Jun
Jia, Lie-ni
Zhang, Xin
Xu, Hong-yu
Hua, Fei
Hu, Xiang-gang
Xie, Qiao
Wang, Wei
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
A drug-loaded membrane was prepared by electrospinning Poly ε-caprolactone (PCL) with doxycycline hydrochloride (DOX) (15–25% w/w).
Scanning electron microscopy (SEM) images revealed that fibrous average diameter decreased from 247.16 ± 57.61 nm to 194.43 ± 43.33 nm with the drug proportion increasing from 15% to 20% w/w, while there was no significant difference between 20% and 25% groups.
The polymer matrix showed good encapsulation value (58–75%) for DOX, and the drug showed an amorphous manner in the polymer matrix.
The agar diffusion test revealed that DOX-loaded membranes had an obvious inhibited effect on Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg), respectively.
In vitro release test showed that DOX could persistently be released for a prolonged time more than 28 days, and the DOX level in the eluent steadied at 3–5 μg/mL which was all above the minimum inhibitory concentration (MIC) of DOX against Aa (0.125 μg/mL) and Pg (0.0625 μg/mL).
Cytocompatibility, assessed in human periodontal ligament cells (hPLCs) by MTT-test and the morphology of cells on the surface of DOX-loaded membranes by SEM, indicated that all of the investigated nanofibrous membranes can be used to treat periodontal disease by integrating the GTR/GBR operation and antibiotic therapy.
Above all, DOX-loaded nanofibrous membranes could have a persistent inhibited effect on periodontal pathogens to provide a relatively sterile environment for tissue repair and regeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jia, Lie-ni& Zhang, Xin& Xu, Hong-yu& Hua, Fei& Hu, Xiang-gang& Xie, Qiao…[et al.]. 2016. Development of a Doxycycline Hydrochloride-Loaded Electrospun Nanofibrous Membrane for GTRGBR Applications. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109315
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jia, Lie-ni…[et al.]. Development of a Doxycycline Hydrochloride-Loaded Electrospun Nanofibrous Membrane for GTRGBR Applications. Journal of Nanomaterials No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1109315
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jia, Lie-ni& Zhang, Xin& Xu, Hong-yu& Hua, Fei& Hu, Xiang-gang& Xie, Qiao…[et al.]. Development of a Doxycycline Hydrochloride-Loaded Electrospun Nanofibrous Membrane for GTRGBR Applications. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109315
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109315
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر