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Nanoformulation of Premixing Propofol Lipid Emulsion and Fentanyl Citrate and Their Effects on Acute Toxicity, Sedation, and Analgesia
المؤلفون المشاركون
Shen, Xin
Gao, Wei
Sha, Baoyong
Fan, Zhe
Liu, Yansheng
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
To illustrate the effects of premixing propofol lipid emulsion (PLE) and fentanyl citrate (FC) on acute toxicity, sedation, and analgesia, sixty female mice were randomly assigned to individual and premixed groups.
The median lethal dose (LD50), median effective dose (ED50) of loss of righting reflex, and ED50 of tail flick test in both groups were determined using the up and down procedure (FC : PLE = 1 μg : 2 mg).
PLE was immediately administered to the mice from the individual group via the tail vein after injecting FC.
By contrast, FC was mixed with PLE before injection from the premixed group.
No significant differences in LD50, histopathological examination, and ED50 sedation value were found between the groups.
However, ED50 of analgesia in the premixed group decreased to half of that in the individual group.
Transmission electron microscopic observation revealed ~10 nm fusiform particles at the juncture of 200–300 nm particles in the mixture of PLE and FC compared with the single PLE and its mixture with saline, which may be attributed to the structure of FC.
In conclusion, premixing PLE and FC enhanced synergic analgesia twofold but did not influence toxicity and sedation compared with individual injections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Wei& Sha, Baoyong& Fan, Zhe& Liu, Yansheng& Shen, Xin. 2016. Nanoformulation of Premixing Propofol Lipid Emulsion and Fentanyl Citrate and Their Effects on Acute Toxicity, Sedation, and Analgesia. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109427
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Wei…[et al.]. Nanoformulation of Premixing Propofol Lipid Emulsion and Fentanyl Citrate and Their Effects on Acute Toxicity, Sedation, and Analgesia. Journal of Nanomaterials No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109427
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Wei& Sha, Baoyong& Fan, Zhe& Liu, Yansheng& Shen, Xin. Nanoformulation of Premixing Propofol Lipid Emulsion and Fentanyl Citrate and Their Effects on Acute Toxicity, Sedation, and Analgesia. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109427
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109427
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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