Evaluation of Antioxidant Ability In Vitro and Bioavailability of trans-Cinnamic Acid Nanoparticle by Liquid Antisolvent Precipitate
المؤلفون المشاركون
Zu, Yuangang
Zhao, Xiuhua
Li, Wengang
Sun, Xiaoli
Liu, Ying
Ge, Yunlong
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-31
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
TCD is a kind of organic acid that is isolated from cinnamon bark or benzoin.
TCD has significant antioxidant activity and is widely used in pharmaceutical, cosmetic, and food additives.
But TCD has shortcomings of low bioavailability due to poor water solubility.
Therefore, we use ethanol as a solvent, deionized water as antisolvent, and hydroxypropyl methylcellulose (HPMC) as the surfactant to prepare TCD nanoparticle powder.
The optimum preparation conditions were determined as follows: TCD-ethanol solution concentration was 170 mg/mL, the volume ratio of antisolvent was 4 times that of solvent, and the amount of the surfactant was 0.3% stirred for 10 min by 2500 rpm; TCD nanoparticle with a mean particle size (MPS) of 130±12.5 nm is obtained under the optimum conditions.
SEM, FT-IR, LC-MS/MS, XRD, and DSC were used to characterize the TCD nanoparticle.
The results showed that the chemical structure of TCD nanoparticle was not changed, but the crystallization was significantly reduced.
Solubility, dissolution rate, antioxidant activity, the in vitro transdermal penetration, and bioavailability of TCD nanoparticles were all much better than these of the raw TCD.
These results suggested that TCD nanoparticle might have potential value to become a new oral or transdermal TCD formulation with high bioavailability.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Wengang& Zhao, Xiuhua& Sun, Xiaoli& Zu, Yuangang& Liu, Ying& Ge, Yunlong. 2016. Evaluation of Antioxidant Ability In Vitro and Bioavailability of trans-Cinnamic Acid Nanoparticle by Liquid Antisolvent Precipitate. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1109512
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Wengang…[et al.]. Evaluation of Antioxidant Ability In Vitro and Bioavailability of trans-Cinnamic Acid Nanoparticle by Liquid Antisolvent Precipitate. Journal of Nanomaterials No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1109512
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Wengang& Zhao, Xiuhua& Sun, Xiaoli& Zu, Yuangang& Liu, Ying& Ge, Yunlong. Evaluation of Antioxidant Ability In Vitro and Bioavailability of trans-Cinnamic Acid Nanoparticle by Liquid Antisolvent Precipitate. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1109512
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109512
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر