Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice
المؤلفون المشاركون
Cao, Jian
Abraham, Nader G.
Singh, Shailendra P.
Falck, John R.
Kappas, Attallah
Vanella, Luca
Bellner, Lars
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-20
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Background/Objectives.
Obesity and metabolic syndrome and associated adiposity are a systemic condition characterized by increased mitochondrial dysfunction, inflammation, and inhibition of antioxidant genes, HO-1, and EETs levels.
We postulate that EETs attenuate adiposity by stimulating mitochondrial function and induction of HO-1 via activation of PGC-1α in adipose and hepatic tissue.
Methods.
Cultured murine adipocytes and mice fed a high fat (HF) diet were used to assess the functional relationship among EETs, PGC-1α, HO-1, and mitochondrial signaling using an EET-agonist (EET-A) and PGC-1α-deficient cells and mice using lentiviral PGC-1α(sh).
Results.
EET-A is a potent inducer of PGC-1α, HO-1, mitochondrial biogenesis (cytochrome oxidase subunits 1 and 4 and SIRT3), fusion proteins (Mfn 1/2 and OPA1) and fission proteins (DRP1 and FIS1) (p<0.05), fasting glucose, BW, and blood pressure.
These beneficial effects were prevented by administration of lenti-PGC-1α(sh).
EET-A administration prevented HF diet induced mitochondrial and dysfunction in adipose tissue and restored VO2 effects that were abrogated in PGC-1α-deficient mice.
Conclusion.
EET is identified as an upstream positive regulator of PGC-1α that leads to increased HO-1, decreased BW and fasting blood glucose and increased insulin receptor phosphorylation, that is, increased insulin sensitivity and mitochondrial integrity, and possible use of EET-agonist for treatment of obesity and metabolic syndrome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Singh, Shailendra P.& Bellner, Lars& Vanella, Luca& Cao, Jian& Falck, John R.& Kappas, Attallah…[et al.]. 2016. Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice. Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1109617
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Singh, Shailendra P.…[et al.]. Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice. Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1109617
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Singh, Shailendra P.& Bellner, Lars& Vanella, Luca& Cao, Jian& Falck, John R.& Kappas, Attallah…[et al.]. Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice. Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1109617
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109617
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر