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Low Level of Microsatellite Instability Correlates with Poor Clinical Prognosis in Stage II Colorectal Cancer Patients
المؤلفون المشاركون
Mojarad, Ehsan Nazemalhosseini
Kashfi, Seyed Mohammad Hossein
Mirtalebi, Hanieh
Taleghani, Mohammad Yaghoob
Azimzadeh, Pedram
Savabkar, Sanaz
Pourhoseingholi, Mohammad Amin
Jalaeikhoo, Hasan
Asadzadeh Aghdaei, Hamid
Zali, Mohammad Reza
Kuppen, Peter J. K.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The influence of microsatellite instability (MSI) on the prognosis of colorectal cancer (CRC) requires more investigation.
We assessed the role of MSI status in survival of individuals diagnosed with primary colorectal cancer.
In this retrospective cross-sectional study the MSI status was determined in 158 formalin-fixed paraffin-embedded tumors and their matched normal tissues from patients who underwent curative surgery.
Cox proportional hazard modeling was performed to assess the clinical prognostic significance.
In this study we found that MSI-H tumors were predominantly located in the colon versus rectum ( p = 0 .
03 ), associated with poorer differentiation ( p = 0 .
003 ) and TNM stage II/III of tumors ( p = 0 .
02 ).
In CRC patients with stage II, MSI-L cases showed significantly poorer survival compared with patients who had MSI-H or MSS tumors ( p = 0 .
04 ).
This study indicates that MSI-L tumors correlate with poorer clinical outcome in patients with stage II tumors ( p = 0 .
04 ) or in tumors located in the colon ( p = 0 .
02 ).
MSI-L characterizes a distinct subgroup of CRC patients who have a poorer outcome.
This study suggests that MSI status in CRC, as a clinical prognostic marker, is dependent on other factors, such as tumor stage and location.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mojarad, Ehsan Nazemalhosseini& Kashfi, Seyed Mohammad Hossein& Mirtalebi, Hanieh& Taleghani, Mohammad Yaghoob& Azimzadeh, Pedram& Savabkar, Sanaz…[et al.]. 2016. Low Level of Microsatellite Instability Correlates with Poor Clinical Prognosis in Stage II Colorectal Cancer Patients. Journal of Oncology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109689
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mojarad, Ehsan Nazemalhosseini…[et al.]. Low Level of Microsatellite Instability Correlates with Poor Clinical Prognosis in Stage II Colorectal Cancer Patients. Journal of Oncology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109689
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mojarad, Ehsan Nazemalhosseini& Kashfi, Seyed Mohammad Hossein& Mirtalebi, Hanieh& Taleghani, Mohammad Yaghoob& Azimzadeh, Pedram& Savabkar, Sanaz…[et al.]. Low Level of Microsatellite Instability Correlates with Poor Clinical Prognosis in Stage II Colorectal Cancer Patients. Journal of Oncology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109689
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109689
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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