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Correlation of Beta-2 Adrenergic Receptor Expression in Tumor-Free Surgical Margin and at the Invasive Front of Oral Squamous Cell Carcinoma
المؤلفون المشاركون
Nonogaki, Suely
Lauand, Gustavo Amaral
Assao, Agnes
Suárez-Peñaranda, José-Manuel
Pérez-Sayáns, Mario
García-García, Abel
Marana, Aparecido Nilceu
Lauris, José Roberto Pereira
Bravo-Calderón, Diego Maurício
Oliveira, Denise Tostes
Kowalski, Luiz Paulo
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The beta-2 adrenergic receptor is expressed by neoplastic cells and is correlated with a wide spectrum of tumor cell mechanisms including proliferation, apoptosis, angiogenesis, migration, and metastasis.
Objectives.
The present study aimed to analyze the expression of the beta-2 adrenergic receptor (β2-AR) in tumor-free surgical margins of oral squamous cell carcinomas (OSCC) and at the invasive front.
Sixty-two patients diagnosed with OSCC, confirmed by biopsy, were selected for the study.
The clinicopathological data and clinical follow-up were obtained from medical records and their association with β2-AR expression was verified by the chi-square test or Fischer’s exact test.
To verify the correlation of β2-AR expression in tumor-free surgical margins and at the invasive front of OSCCs, Pearson’s correlation coefficient test was applied.
Results.
The expression of β2-AR presented a statistically significant correlation between the tumor-free surgical margins and the invasive front of OSCC (r=0.383; p=0.002).
The immunohistochemical distribution of β2-AR at the invasive front of OSCC was also statistically significant associated with alcohol (p=0.038), simultaneous alcohol and tobacco consumption (p=0.010), and T stage (p=0.014).
Conclusions.
The correlation of β2-AR expression in OSCC and tumor-free surgical margins suggests a role of this receptor in tumor progression and its expression in normal oral epithelium seems to be constitutive.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oliveira, Denise Tostes& Bravo-Calderón, Diego Maurício& Lauand, Gustavo Amaral& Assao, Agnes& Suárez-Peñaranda, José-Manuel& Pérez-Sayáns, Mario…[et al.]. 2016. Correlation of Beta-2 Adrenergic Receptor Expression in Tumor-Free Surgical Margin and at the Invasive Front of Oral Squamous Cell Carcinoma. Journal of Oncology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109695
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oliveira, Denise Tostes…[et al.]. Correlation of Beta-2 Adrenergic Receptor Expression in Tumor-Free Surgical Margin and at the Invasive Front of Oral Squamous Cell Carcinoma. Journal of Oncology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109695
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oliveira, Denise Tostes& Bravo-Calderón, Diego Maurício& Lauand, Gustavo Amaral& Assao, Agnes& Suárez-Peñaranda, José-Manuel& Pérez-Sayáns, Mario…[et al.]. Correlation of Beta-2 Adrenergic Receptor Expression in Tumor-Free Surgical Margin and at the Invasive Front of Oral Squamous Cell Carcinoma. Journal of Oncology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109695
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109695
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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