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Changes in Pathological Complete Response Rates after Neoadjuvant Chemotherapy for Breast Carcinoma over Five Years
المؤلفون المشاركون
Tiersten, Amy
Bleiweiss, Ira
McFarland, Daniel
Naikan, Jessica
Rozenblit, Mariya
Mandeli, John
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-13
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Historically, neoadjuvant chemotherapy (NACT) was extrapolated from adjuvant regimens.
Dual HER2 blockade and the introduction of carboplatin for triple negative breast cancers (TNBC) emerged by December 2013 and have improved pathological complete response (pCR) rates.
The objective of this study was to assess the pCR rates before and after the introduction of these new neoadjuvant regimens.
Materials and Methods.
Stage I–III breast cancer patients who received NACT were analyzed for rates of pCR by clinical characteristics (i.e., age, BMI, axillary lymphadenopathy, and histologic subtype), by time period (1 = 3/2010–11/2013, 2 = 12/2013–3/2015), and by type of chemotherapy (e.g., anthracycline/taxane only, carboplatin-containing, and HER2 blockade).
Results.
113 patients received NACT.
Overall pCR rate was 26.5 percent ( n = 30 ).
The pCR rate increased from 14% to 43.1% ( p = 0 .
001 ) from time period 1 to time period 2 and were associated with HER2 positivity ( p = 0 .
003 ), receiving treatment during time period 2 ( p = 0 .
001 ) and using an anthracycline/taxane plus additional agent type of regimen ( p = 0 .
004 ).
Conclusions.
Our study revealed a significant difference in rates of pCR over five years.
Window of opportunity trials and other trials that utilize pCR analysis should be encouraged.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
McFarland, Daniel& Naikan, Jessica& Rozenblit, Mariya& Mandeli, John& Bleiweiss, Ira& Tiersten, Amy. 2016. Changes in Pathological Complete Response Rates after Neoadjuvant Chemotherapy for Breast Carcinoma over Five Years. Journal of Oncology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1109697
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
McFarland, Daniel…[et al.]. Changes in Pathological Complete Response Rates after Neoadjuvant Chemotherapy for Breast Carcinoma over Five Years. Journal of Oncology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1109697
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
McFarland, Daniel& Naikan, Jessica& Rozenblit, Mariya& Mandeli, John& Bleiweiss, Ira& Tiersten, Amy. Changes in Pathological Complete Response Rates after Neoadjuvant Chemotherapy for Breast Carcinoma over Five Years. Journal of Oncology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1109697
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109697
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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