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Study of the Effects of Betaine andor C-Phycocyanin on the Growth of Lung Cancer A549 Cells In Vitro and In Vivo
المؤلفون المشاركون
Pichon, C.
Bingula, Rea
Dupuis, Carmen
Berthon, Jean-Yves
Filaire, Marc
Pigeon, Lucie
Filaire, Edith
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We investigated the effects of betaine, C-phycocyanin (C-PC), and their combined use on the growth of A549 lung cancer both in vitro and in vivo.
When cells were coincubated with betaine and C-PC, an up to 60% decrease in viability was observed which is significant compared to betaine (50%) or C-PC treatment alone (no decrease).
Combined treatment reduced the stimulation of NF-κB expression by TNF-α and increased the amount of the proapoptotic p38 MAPK.
Interestingly, combined treatment induced a cell cycle arrest in G2/M phase for ~60% of cells.
In vivo studies were performed in pathogen-free male nude rats injected with A549 cells in their right flank.
Their daily food was supplemented with either betaine, C-PC, both, or neither.
Compared to the control group, tumour weights and volumes were significantly reduced in either betaine- or C-PC-treated groups and no additional decrease was obtained with the combined treatment.
This data indicates that C-PC and betaine alone may efficiently inhibit tumour growth in rats.
The synergistic activity of betaine and C-PC on A549 cells growth observed in vitro remains to be further confirmed in vivo.
The reason behind the nature of their interaction is yet to be sought.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bingula, Rea& Dupuis, Carmen& Pichon, C.& Berthon, Jean-Yves& Filaire, Marc& Pigeon, Lucie…[et al.]. 2016. Study of the Effects of Betaine andor C-Phycocyanin on the Growth of Lung Cancer A549 Cells In Vitro and In Vivo. Journal of Oncology،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1109712
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bingula, Rea…[et al.]. Study of the Effects of Betaine andor C-Phycocyanin on the Growth of Lung Cancer A549 Cells In Vitro and In Vivo. Journal of Oncology No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1109712
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bingula, Rea& Dupuis, Carmen& Pichon, C.& Berthon, Jean-Yves& Filaire, Marc& Pigeon, Lucie…[et al.]. Study of the Effects of Betaine andor C-Phycocyanin on the Growth of Lung Cancer A549 Cells In Vitro and In Vivo. Journal of Oncology. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1109712
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109712
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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