Unhealthy Phenotype as Indicated by Salivary Biomarkers: Glucose, Insulin, VEGF-A, and IL-12p70 in Obese Kuwaiti Adolescents
المؤلفون المشاركون
Behbehani, Kazem
Hartman, Mor-Li
Goodson, J. Max
Shi, Ping
Vargas, Jorel
Yaskell, Tina
Stephens, Danielle
Cugini, Maryann
Hasturk, Hatice
Barake, Roula
Al-Mutawa, Sabiha
Ariga, Jitendra
Soparkar, Pramod
Behbehani, Jawad
Welty, Francine
Alsmadi, Osama
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
Here, we investigated the relationships between obesity and the salivary concentrations of insulin, glucose, and 20 metabolic biomarkers in Kuwaiti adolescents.
Previously, we have shown that certain salivary metabolic markers can act as surrogates for blood concentrations.
Methods.
Salivary samples of whole saliva were collected from 8,317 adolescents.
Salivary glucose concentration was measured by a high-sensitivity glucose oxidase method implemented on a robotic chemical analyzer.
The concentration of salivary insulin and 20 other metabolic biomarkers was assayed in 744 randomly selected saliva samples by multiplexed bead-based immunoassay.
Results.
Obesity was seen in 26.5% of the adolescents.
Salivary insulin predicting hyperinsulinemia occurred in 4.3% of normal-weight adolescents, 8.3% of overweight adolescents, and 25.7% of obese adolescents (p<0.0001).
Salivary glucose predicting hyperglycemia was found in only 3% of obese children and was not predictive (p=0.89).
Elevated salivary glucose and insulin occurring together was associated with elevated vascular endothelial growth factor and reduced salivary interleukin-12.
Conclusion.
Considering the surrogate nature of salivary insulin and glucose, this study suggests that elevated insulin may be a dominant sign of metabolic disease in adolescent populations.
It also appears that a proangiogenic environment may accompany elevated glucose in obese adolescents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hartman, Mor-Li& Goodson, J. Max& Shi, Ping& Vargas, Jorel& Yaskell, Tina& Stephens, Danielle…[et al.]. 2016. Unhealthy Phenotype as Indicated by Salivary Biomarkers: Glucose, Insulin, VEGF-A, and IL-12p70 in Obese Kuwaiti Adolescents. Journal of Obesity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109756
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hartman, Mor-Li…[et al.]. Unhealthy Phenotype as Indicated by Salivary Biomarkers: Glucose, Insulin, VEGF-A, and IL-12p70 in Obese Kuwaiti Adolescents. Journal of Obesity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109756
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hartman, Mor-Li& Goodson, J. Max& Shi, Ping& Vargas, Jorel& Yaskell, Tina& Stephens, Danielle…[et al.]. Unhealthy Phenotype as Indicated by Salivary Biomarkers: Glucose, Insulin, VEGF-A, and IL-12p70 in Obese Kuwaiti Adolescents. Journal of Obesity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109756
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109756
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر