Altered Left Ventricular Ion Channel Transcriptome in a High-Fat-Fed Rat Model of Obesity: Insight into Obesity-Induced Arrhythmogenesis

المؤلفون المشاركون

Davis, Gershan
Ashrafi, Reza
Yon, Marianne
Pickavance, Lucy
Yanni Gerges, Joseph
Wilding, John
Jian, Kun
Hart, George
Boyett, Mark
Zhang, Henggui

المصدر

Journal of Obesity

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-09-25

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الطب البشري

الملخص EN

Introduction.

Obesity is increasingly common and is associated with an increased prevalence of cardiac arrhythmias.

The aim of this study was to see whether in obesity there is proarrhythmic gene expression of ventricular ion channels and related molecules.

Methods and Results.

Rats were fed on a high-fat diet and compared to control rats on a normal diet ( n = 8 ).

After 8 weeks, rats on the high-fat diet showed significantly greater weight gain and higher adiposity.

Left ventricle samples were removed at 8 weeks and mRNA expression of ion channels and other molecules was measured using qPCR.

Obese rats had significant upregulation of C a v 1.2 , HCN4, K i r 2.1 , RYR2, NCX1, SERCA2a, and RYR2 mRNA and downregulation of ERG mRNA.

In the case of HCN4, it was confirmed that there was a significant increase in protein expression.

The potential effects of the mRNA changes on the ventricular action potential and intracellular Ca2+ transient were predicted using computer modelling.

Modelling predicted prolongation of the ventricular action potential and an increase in the intracellular Ca2+ transient, both of which would be expected to be arrhythmogenic.

Conclusion.

High-fat diet causing obesity results in arrhythmogenic cardiac gene expression of ion channels and related molecules.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ashrafi, Reza& Yon, Marianne& Pickavance, Lucy& Yanni Gerges, Joseph& Davis, Gershan& Wilding, John…[et al.]. 2016. Altered Left Ventricular Ion Channel Transcriptome in a High-Fat-Fed Rat Model of Obesity: Insight into Obesity-Induced Arrhythmogenesis. Journal of Obesity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1109757

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ashrafi, Reza…[et al.]. Altered Left Ventricular Ion Channel Transcriptome in a High-Fat-Fed Rat Model of Obesity: Insight into Obesity-Induced Arrhythmogenesis. Journal of Obesity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1109757

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ashrafi, Reza& Yon, Marianne& Pickavance, Lucy& Yanni Gerges, Joseph& Davis, Gershan& Wilding, John…[et al.]. Altered Left Ventricular Ion Channel Transcriptome in a High-Fat-Fed Rat Model of Obesity: Insight into Obesity-Induced Arrhythmogenesis. Journal of Obesity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1109757

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1109757