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The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial
المؤلفون المشاركون
van der Aa, M. P.
Knibbe, C. A. J.
de Boer, A.
van der Vorst, M. M. J.
Hoving, Vera
van de Garde, Ewoudt M. W.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
In a recent randomized controlled trial (RCT) in obese adolescents, 18 month-treatment with metformin versus placebo was reported to lead to stabilisation of the BMI.
This study aimed to compare the effect of metformin on BMI in obese adolescents in daily practice versus results obtained in an RCT.
Methods.
Obese adolescents treated off label with metformin in daily practice in an outpatient clinic with a follow-up of ≥18 months were identified.
Anthropometric and biochemical data were collected at baseline and at 18 months.
Patients treated with metformin for 18 months in an RCT were used for comparison.
BMI was compared between the two groups.
Results.
Nineteen patients (median age 14.3 (interquartile range 11.7–15.7) years, BMI 31.3 (28.8–33.8) kg/m2) treated in daily practice were compared to 23 patients receiving metformin in the RCT (age 13.6 (12.6–15.3) years, BMI 29.8 (28.1–34.5) kg/m2).
BMI change after 18 months was −0.36 (−2.10–1.58) versus +0.22 (−2.87–1.27) kg/m2 for the two groups, respectively.
In the multivariable model, BMI change was not statistically significantly different between the two groups (p=0.61).
Conclusion.
Treatment with metformin in obese adolescents in daily practice resulted in a comparable change in BMI as observed in an RCT.
This trial is registered with ClinicalTrials.gov number: NCT01487993.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
van der Aa, M. P.& Hoving, Vera& van de Garde, Ewoudt M. W.& de Boer, A.& Knibbe, C. A. J.& van der Vorst, M. M. J.. 2016. The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial. Journal of Obesity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109769
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
van der Aa, M. P.…[et al.]. The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial. Journal of Obesity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1109769
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
van der Aa, M. P.& Hoving, Vera& van de Garde, Ewoudt M. W.& de Boer, A.& Knibbe, C. A. J.& van der Vorst, M. M. J.. The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial. Journal of Obesity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109769
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109769
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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