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Propolis, a Constituent of Honey, Inhibits the Development of Sugar Cataracts and High-Glucose-Induced Reactive Oxygen Species in Rat Lenses
المؤلفون المشاركون
Shibata, Teppei
Shibata, Shinsuke
Shibata, Naoko
Kiyokawa, Etsuko
Sasaki, Hiroshi
Singh, Dhirendra P.
Kubo, Eri
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-08
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Purpose.
This study investigated the effects of oral propolis on the progression of galactose-induced sugar cataracts in rats and the in vitro effects of propolis on high-glucose-induced reactive oxygen species (ROS) and cell death in cultured rat lens cells (RLECs).
Methods.
Galactose-fed rats and RLECs cultured in high glucose (55 mM) medium were treated with propolis or vehicle control.
Relative lens opacity was assessed by densitometry and changes in lens morphology by histochemical analysis.
Intracellular ROS levels and cell viability were measured.
Results.
Oral administration of propolis significantly inhibited the onset and progression of cataract in 15% and 25% of galactose-fed rats, respectively.
RLECs cultured with high glucose showed a significant increase in ROS expression with reduced cell viability.
Treatment of these RLECs with 5 and 50 μg/mL propolis cultured significantly reduced ROS levels and increased cell viability, indicating that the antioxidant activity of propolis protected cells against ROS-induced damage.
Conclusion.
Propolis significantly inhibited the onset and progression of sugar cataract in rats and mitigated high-glucose-induced ROS production and cell death.
These effects may be associated with the ability of propolis to inhibit hyperglycemia-evoked oxidative or osmotic stress-induced cellular insults.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shibata, Teppei& Shibata, Shinsuke& Shibata, Naoko& Kiyokawa, Etsuko& Sasaki, Hiroshi& Singh, Dhirendra P.…[et al.]. 2016. Propolis, a Constituent of Honey, Inhibits the Development of Sugar Cataracts and High-Glucose-Induced Reactive Oxygen Species in Rat Lenses. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109872
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shibata, Teppei…[et al.]. Propolis, a Constituent of Honey, Inhibits the Development of Sugar Cataracts and High-Glucose-Induced Reactive Oxygen Species in Rat Lenses. Journal of Ophthalmology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1109872
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shibata, Teppei& Shibata, Shinsuke& Shibata, Naoko& Kiyokawa, Etsuko& Sasaki, Hiroshi& Singh, Dhirendra P.…[et al.]. Propolis, a Constituent of Honey, Inhibits the Development of Sugar Cataracts and High-Glucose-Induced Reactive Oxygen Species in Rat Lenses. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109872
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109872
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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