Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations
المؤلفون المشاركون
Bonferoni, Maria Cristina
Facskó, Andrea
Budai-Szűcs, Mária
Horvát, Gabriella
Szilágyi, Barnabás Áron
Gyarmati, Benjámin
Szilágyi, András
Sandri, Giuseppina
Caramella, Carla
Soós, Judit
Berkó, Szilvia
Szabó-Révész, Piroska
Csányi, Erzsébet
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life.
The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film.
A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N′,N′-dimethylaminoethyl)aspartamide)] (ThioPASP-DME), was used as a potential vehicle.
Besides satisfying the basic requirements, the chemical structure of ThioPASP-DME is similar to those of ocular mucins as it is a protein-like polymer bearing a considerable number of thiol groups.
The solution of the polymer is therefore able to mimic the physiological properties of the mucins and it can interact with the mucus layer via disulphide bond formation.
The resultant mucoadhesion provides a prolonged residence time and ensures protective effect for the corneal/conjunctival epithelium.
ThioPASP-DME also has an antioxidant effect due to the presence of the thiol groups.
The applicability of ThioPASP-DME as a potential excipient in eye drops was determined by means of ocular compatibility tests and through examinations of the interactions with the mucosal surface.
The results indicate that ThioPASP-DME can serve as a potential eye drop excipient for the therapy of dry eye disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Budai-Szűcs, Mária& Horvát, Gabriella& Szilágyi, Barnabás Áron& Gyarmati, Benjámin& Szilágyi, András& Berkó, Szilvia…[et al.]. 2016. Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109898
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Budai-Szűcs, Mária…[et al.]. Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations. Journal of Ophthalmology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109898
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Budai-Szűcs, Mária& Horvát, Gabriella& Szilágyi, Barnabás Áron& Gyarmati, Benjámin& Szilágyi, András& Berkó, Szilvia…[et al.]. Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109898
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109898
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر