Hyaluronate Acid-Dependent Protection and Enhanced Corneal Wound Healing against Oxidative Damage in Corneal Epithelial Cells
المؤلفون المشاركون
Ling, Shiqi
Zhong, Jing
Deng, Yuqing
Tian, Bishan
Wang, Bowen
Sun, Yifang
Huang, Haixiang
Chen, Ling
Yuan, Jin
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Purpose.
To evaluate the effects and mechanism of exogenous hyaluronate (HA) in promoting corneal wound healing.
Methods.
Human corneal epithelial cells (HCECs) were incubated with different concentrations of HA to evaluate their efficiency in promoting cell migration and their modulation of repair factors.
After inducing hyperosmolar conditions, the cell morphologies, cell apoptosis, and expression levels of TNF-α and MMP-9 were detected to assess the protective role of HA.
Corneal epithelium-injured rat models were established to test the therapeutic effects of 0.3% HA.
Then, the wound healing rates, the RNA expression levels of inflammatory cytokines, and repair factors were examined.
Results.
HCECs in the 0.03% and 0.3% HA groups showed fewer morphological alterations and lower rates of cell apoptosis following preincubation with HA under hyperosmolar conditions, as well as the expression levels of MMP-9 and TNF-α.
In the rat model, the areas of fluorescein staining in the corneas of 0.3% HA group were significantly smaller than the control group.
The expression levels of IL-1β and MMP-9 were decreased, while CD44 and FN were increased in the 0.3% HA group.
Conclusion.
HA enhanced corneal epithelial cell wound healing by promoting cell migration, upregulating repair responses, and suppressing inflammatory responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhong, Jing& Deng, Yuqing& Tian, Bishan& Wang, Bowen& Sun, Yifang& Huang, Haixiang…[et al.]. 2016. Hyaluronate Acid-Dependent Protection and Enhanced Corneal Wound Healing against Oxidative Damage in Corneal Epithelial Cells. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110032
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhong, Jing…[et al.]. Hyaluronate Acid-Dependent Protection and Enhanced Corneal Wound Healing against Oxidative Damage in Corneal Epithelial Cells. Journal of Ophthalmology No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1110032
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhong, Jing& Deng, Yuqing& Tian, Bishan& Wang, Bowen& Sun, Yifang& Huang, Haixiang…[et al.]. Hyaluronate Acid-Dependent Protection and Enhanced Corneal Wound Healing against Oxidative Damage in Corneal Epithelial Cells. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110032
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110032
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر