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In Vivo Antimalarial Activity of Annona muricata Leaf Extract in Mice Infected with Plasmodium berghei
المؤلفون المشاركون
Chachiyo, Sukanya
Somsak, Voravuth
Polwiang, Natsuda
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-22
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Malaria is one of the most important infectious diseases in the world.
The choice for the treatment is highly limited due to drug resistance.
Hence, finding the new compounds to treat malaria is urgently needed.
The present study was attempted to evaluate the antimalarial activity of the Annona muricata aqueous leaf extract in Plasmodium berghei infected mice.
Aqueous leaf extract of A.
muricata was prepared and tested for acute toxicity in mice.
For efficacy test in vivo, standard 4-day suppressive test was carried out.
ICR mice were inoculated with 107 parasitized erythrocytes of P.
berghei ANKA by intraperitoneal injection.
The extracts (100, 500, and 1000 mg/kg) were then given orally by gavage once a day for 4 consecutive days.
Parasitemia, percentage of inhibition, and packed cell volume were subsequently calculated.
Chloroquine (10 mg/kg) was given to infected mice as positive control while untreated control was given only distilled water.
It was found that A.
muricata aqueous leaf extract at doses of 100, 500, and 1000 mg/kg resulted in dose dependent parasitemia inhibition of 38.03%, 75.25%, and 85.61%, respectively.
Survival time was prolonged in infected mice treated with the extract.
Moreover, no mortality to mice was observed with this extract up to a dose of 4000 mg/kg.
In conclusion, the A.
muricata aqueous leaf extract exerted significant antimalarial activity with no toxicity and prolonged survival time.
Therefore, this extract might contain potential lead molecule for the development of a new drug for malaria treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Somsak, Voravuth& Polwiang, Natsuda& Chachiyo, Sukanya. 2016. In Vivo Antimalarial Activity of Annona muricata Leaf Extract in Mice Infected with Plasmodium berghei. Journal of Pathogens،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1110204
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Somsak, Voravuth…[et al.]. In Vivo Antimalarial Activity of Annona muricata Leaf Extract in Mice Infected with Plasmodium berghei. Journal of Pathogens No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1110204
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Somsak, Voravuth& Polwiang, Natsuda& Chachiyo, Sukanya. In Vivo Antimalarial Activity of Annona muricata Leaf Extract in Mice Infected with Plasmodium berghei. Journal of Pathogens. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1110204
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110204
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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