Phenotypic Detection of Metallo-Beta-Lactamases in Carbapenem Resistant Acinetobacter baumannii Isolated from Pediatric Patients in Pakistan
المؤلفون المشاركون
Anwar, Muneeza
Ejaz, Hassan
Zafar, Aizza
Hamid, Hamdan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Multidrug resistant A.
baumannii has emerged as an important and problematic human pathogen as it is the causative agent of several types of infections especially in neonates and immunocompromised patients because they have least capacity to fight against infections.
Carbapenems are used as last resort antibiotics for treating these infections but currently resistance against carbapenems due to MBL production is on the rise.
The objective of this study was to determine the frequency of antibiotic resistance in A.
baumannii and also to compare the efficacy of combined disk test and double disk synergy test for detection of metallo-beta-lactamases.
A total of 112 A.
baumannii were identified from various clinical samples and antibiotic susceptibility profile was determined by Kirby-Bauer Disk Diffusion method.
Out of 112, 66 (58.9%) isolates were resistant to both imipenem and meropenem (OXOID).
These resistant isolates were tested for carbapenemase production, and 55 (83.3%) were carbapenemase producers by Modified Hodge Test.
These isolates were further tested for MBL production by combined disk test and double disk synergy test.
Out of 66, 49 isolates were positive by both methods, CDT and DDST, and only one isolate was detected as negative (with kappa value = 0.038).
All MBL producing strains showed remarkable resistance to cephalosporins, fluoroquinolones, aminoglycosides, and piperacillin/tazobactam (OXOID).
The antibiotic resistance was very high in A.
baumannii which were isolated from children in Pakistan specially attending a nephrology unit.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Anwar, Muneeza& Ejaz, Hassan& Zafar, Aizza& Hamid, Hamdan. 2016. Phenotypic Detection of Metallo-Beta-Lactamases in Carbapenem Resistant Acinetobacter baumannii Isolated from Pediatric Patients in Pakistan. Journal of Pathogens،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110219
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Anwar, Muneeza…[et al.]. Phenotypic Detection of Metallo-Beta-Lactamases in Carbapenem Resistant Acinetobacter baumannii Isolated from Pediatric Patients in Pakistan. Journal of Pathogens No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1110219
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Anwar, Muneeza& Ejaz, Hassan& Zafar, Aizza& Hamid, Hamdan. Phenotypic Detection of Metallo-Beta-Lactamases in Carbapenem Resistant Acinetobacter baumannii Isolated from Pediatric Patients in Pakistan. Journal of Pathogens. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110219
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110219
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر