Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths
المؤلفون المشاركون
Gabrie, José Antonio
Rueda, María Mercedes
Rodríguez, Carol Anahelka
Canales, Maritza
Sanchez, Ana Lourdes
المصدر
Journal of Parasitology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Soil-transmitted helminth infections typically induce a type-2 immune response (Th2), but no immunoepidemiological studies have been undertaken in Honduras, an endemic country where the main control strategy is children’s annual deworming.
We aimed to characterize the immune profile of Honduran schoolchildren harbouring these parasitoses.
Demographic and epidemiological data were obtained through a survey; nutritional status was assessed through anthropometry; intestinal parasites were diagnosed by formol-ether and Kato-Katz; and blood samples were collected to determine immunological markers including Th1/Th2 cytokines, IgE, and eosinophil levels.
A total of 225 children participated in the study, all of whom had received deworming during the national campaign five months prior to the study.
Trichuriasis and ascariasis prevalence were 22.2% and 20.4%, respectively.
Stunting was associated with both age and trichuriasis, whereas ascariasis was associated with sex and household conditions.
Helminth infections were strongly associated with eosinophilia and hyper-IgE as well as with a Th2-polarized response (increased levels of IL-13, IL-10, and IL4/IFN- γ ratios and decreased levels of IFN- γ ).
Pathogenic protozoa infections were associated with a Th1 response characterized by elevated levels of IFN- γ and decreased IL10/IFN- γ ratios.
Even at low prevalence levels, STH infections affect children’s nutrition and play a polarizing role in their immune system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gabrie, José Antonio& Rueda, María Mercedes& Rodríguez, Carol Anahelka& Canales, Maritza& Sanchez, Ana Lourdes. 2016. Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths. Journal of Parasitology Research،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1110228
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gabrie, José Antonio…[et al.]. Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths. Journal of Parasitology Research No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1110228
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gabrie, José Antonio& Rueda, María Mercedes& Rodríguez, Carol Anahelka& Canales, Maritza& Sanchez, Ana Lourdes. Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths. Journal of Parasitology Research. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1110228
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110228
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر