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Protective Effect of Vitamins C and E on Depot-Medroxyprogesterone Acetate-Induced Ovarian Oxidative Stress In Vivo
المؤلفون المشاركون
Ismiyati, Atik
Wiyasa, I. Wayan Arsana
Hidayati, Dwi Yuni Nur
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-07
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
A study was designed to investigate ameliorates effect of combined vitamins C and E able to against depot-medroxyprogesterone acetate- (DMPA-) induced ovarian oxidative stress in rat.
Twenty-five female Wistar rats were divided into the following groups (n=5 rats each): control (untreated) (C); depot-medroxyprogesterone acetate (DMPA); DMPA plus green vitamin C (at dose of 0.2 mg/gram; 0.4 mg/gram; 0.8 mg/gram) and vitamin E (0.04 IU/gram).
The treatment with combined vitamins C and E was performed for four weeks.
Analysis of malondialdehyde (MDA) level as a marker of oxidative stress was done colorimetrically.
Analysis of SOD level was done by enzyme linked immunosorbent assay (ELISA) technically.
This increase in ovarium MDA was significantly (P<0.05) attenuated by medium dose treatments of combined vitamins C and E.
DMPA insignificantly decreased SOD levels compared to the untreated group.
This decrease in ovarian SOD level was significantly attenuated by all doses of the combined vitamins C and E.
In conclusion, DMPA induces ovarian oxidative stress.
Combined vitamins C and E prohibit the increase in ovarian lipid peroxidation, at least in part by modulating of superoxide dismutase.
Therefore, this may provide an antioxidant therapy for attenuating the ovarian toxicity found in the DMPA therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ismiyati, Atik& Wiyasa, I. Wayan Arsana& Hidayati, Dwi Yuni Nur. 2016. Protective Effect of Vitamins C and E on Depot-Medroxyprogesterone Acetate-Induced Ovarian Oxidative Stress In Vivo. Journal of Toxicology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1110820
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ismiyati, Atik…[et al.]. Protective Effect of Vitamins C and E on Depot-Medroxyprogesterone Acetate-Induced Ovarian Oxidative Stress In Vivo. Journal of Toxicology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1110820
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ismiyati, Atik& Wiyasa, I. Wayan Arsana& Hidayati, Dwi Yuni Nur. Protective Effect of Vitamins C and E on Depot-Medroxyprogesterone Acetate-Induced Ovarian Oxidative Stress In Vivo. Journal of Toxicology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1110820
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110820
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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