Immunomodulatory Role of Mesenchymal Stem Cell Therapy in Vascularized Composite Allotransplantation
المؤلفون المشاركون
Lott, David G.
Heyes, Richard
Iarocci, Andrew
Tchoukalova, Yourka
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
This review aims to summarize contemporary evidence of the in vitro and in vivo immunomodulatory effects of mesenchymal stem cells (MSCs) in promoting vascularized composite allotransplant (VCA) tolerance.
An extensive literature review was performed to identify pertinent articles of merit.
Prospective preclinical trials in mammal subjects receiving VCA (or skin allograft) with administration of MSCs were reviewed.
Prospective clinical trials with intravascular delivery of MSCs in human populations undergoing solid organ transplant were also identified and reviewed.
Sixteen preclinical studies are included.
Eleven studies compared MSC monotherapy to no therapy; of these, ten reported improved graft survival, which was statistically significantly prolonged in eight.
Eight studies analyzed allograft survival with MSC therapy as an adjunct to proven immunosuppressive regimens.
In these studies, daily immunosuppression was transiently delivered and then stopped.
In all studies, treatment-free graft survival was statistically significantly prolonged in animals that received MSC therapy.
MSCs have been safely administered clinically and their use in renal transplant clinical trials provides evidence that they improve allograft transplant tolerance in clinical practice.
There is potential for MSC induction therapy to overcome many of the obstacles to widespread VCA in clinical practice.
Preclinical studies are needed before MSC-induced VCA tolerance becomes a clinical reality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Heyes, Richard& Iarocci, Andrew& Tchoukalova, Yourka& Lott, David G.. 2016. Immunomodulatory Role of Mesenchymal Stem Cell Therapy in Vascularized Composite Allotransplantation. Journal of Transplantation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110896
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Heyes, Richard…[et al.]. Immunomodulatory Role of Mesenchymal Stem Cell Therapy in Vascularized Composite Allotransplantation. Journal of Transplantation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1110896
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Heyes, Richard& Iarocci, Andrew& Tchoukalova, Yourka& Lott, David G.. Immunomodulatory Role of Mesenchymal Stem Cell Therapy in Vascularized Composite Allotransplantation. Journal of Transplantation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110896
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110896
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر