Immunomodulatory Role of Mesenchymal Stem Cell Therapy in Vascularized Composite Allotransplantation

المؤلفون المشاركون

Lott, David G.
Heyes, Richard
Iarocci, Andrew
Tchoukalova, Yourka

المصدر

Journal of Transplantation

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-10-16

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

This review aims to summarize contemporary evidence of the in vitro and in vivo immunomodulatory effects of mesenchymal stem cells (MSCs) in promoting vascularized composite allotransplant (VCA) tolerance.

An extensive literature review was performed to identify pertinent articles of merit.

Prospective preclinical trials in mammal subjects receiving VCA (or skin allograft) with administration of MSCs were reviewed.

Prospective clinical trials with intravascular delivery of MSCs in human populations undergoing solid organ transplant were also identified and reviewed.

Sixteen preclinical studies are included.

Eleven studies compared MSC monotherapy to no therapy; of these, ten reported improved graft survival, which was statistically significantly prolonged in eight.

Eight studies analyzed allograft survival with MSC therapy as an adjunct to proven immunosuppressive regimens.

In these studies, daily immunosuppression was transiently delivered and then stopped.

In all studies, treatment-free graft survival was statistically significantly prolonged in animals that received MSC therapy.

MSCs have been safely administered clinically and their use in renal transplant clinical trials provides evidence that they improve allograft transplant tolerance in clinical practice.

There is potential for MSC induction therapy to overcome many of the obstacles to widespread VCA in clinical practice.

Preclinical studies are needed before MSC-induced VCA tolerance becomes a clinical reality.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Heyes, Richard& Iarocci, Andrew& Tchoukalova, Yourka& Lott, David G.. 2016. Immunomodulatory Role of Mesenchymal Stem Cell Therapy in Vascularized Composite Allotransplantation. Journal of Transplantation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110896

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Heyes, Richard…[et al.]. Immunomodulatory Role of Mesenchymal Stem Cell Therapy in Vascularized Composite Allotransplantation. Journal of Transplantation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1110896

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Heyes, Richard& Iarocci, Andrew& Tchoukalova, Yourka& Lott, David G.. Immunomodulatory Role of Mesenchymal Stem Cell Therapy in Vascularized Composite Allotransplantation. Journal of Transplantation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110896

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1110896