Hydroxytyrosol Protects against Myocardial IschemiaReperfusion Injury through a PI3KAkt-Dependent Mechanism
المؤلفون المشاركون
Pei, Ying-hao
Chen, Jiao
Xie, Liang
Cai, Xiao-min
Yang, Run-Hua
Wang, Xing
Gong, Jian-bin
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effects and mechanisms of hydroxytyrosol (HT) during the pathogenesis of myocardial ischemia reperfusion (I/R) in rat hearts.
Methods.
The rats were randomized into five groups: sham group, I/R group, HT+I/R group, HT+LY294002+I/R group, and LY+I/R group.
Myocardial infarct size, markers of oxidative stress, extent of myocardial apoptosis, echocardiographically assessed cardiac function, and expression of Akt and GSK 3β were measured in each group.
Results.
Prereperfusion administration of HT was associated with a significantly smaller area of myocardial infarction and remarkably decreased level of myocardial apoptosis and necrosis, as evidenced by a lower apoptotic index, reduced cleaved caspase-3, and the serum activities of lactate dehydrogenase and creatinine kinase MB.
Moreover, HT also attenuated the impairment of cardiac systolic function.
However, cotreatment with LY294002 and HT completely abolished the above cardioprotective effects of HT.
A subsequent mechanistic study revealed that the cardioprotective effects of HT during the process of I/R of the myocardium were dependent on the activation of the Akt/GSK3β pathway.
Conclusion.
Pretreatment with HT may have antiapoptotic and cardioprotective effects against myocardial I/R injury, and these effects seem to be related to the activation of the Akt/GSK3β pathway in the myocardium.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pei, Ying-hao& Chen, Jiao& Xie, Liang& Cai, Xiao-min& Yang, Run-Hua& Wang, Xing…[et al.]. 2016. Hydroxytyrosol Protects against Myocardial IschemiaReperfusion Injury through a PI3KAkt-Dependent Mechanism. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110922
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pei, Ying-hao…[et al.]. Hydroxytyrosol Protects against Myocardial IschemiaReperfusion Injury through a PI3KAkt-Dependent Mechanism. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1110922
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pei, Ying-hao& Chen, Jiao& Xie, Liang& Cai, Xiao-min& Yang, Run-Hua& Wang, Xing…[et al.]. Hydroxytyrosol Protects against Myocardial IschemiaReperfusion Injury through a PI3KAkt-Dependent Mechanism. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110922
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110922
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر