Doxycycline Inhibits IL-17-Stimulated MMP-9 Expression by Downregulating ERK12 Activation: Implications in Myogenic Differentiation
المؤلفون المشاركون
Mojsilović, Slavko
Bugarski, Diana
Trivanović, Drenka
Obradović, Hristina
Krstić, Jelena
Kukolj, Tamara
Đorđević, Ivana Okić
Jovčić, Gordana
Krstić, Aleksandra
Santibanez, Juan F.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Interleukin 17 (IL-17) is a cytokine with pleiotropic effects associated with several inflammatory diseases.
Although elevated levels of IL-17 have been described in inflammatory myopathies, its role in muscle remodeling and regeneration is still unknown.
Excessive extracellular matrix degradation in skeletal muscle is an important pathological consequence of many diseases involving muscle wasting.
In this study, the role of IL-17 on the expression of matrix metalloproteinase- (MMP-) 9 in myoblast cells was investigated.
The expression of MMP-9 after IL-17 treatment was analyzed in mouse myoblasts C2C12 cell line.
The increase in MMP-9 production by IL-17 was concomitant with its capacity to inhibit myogenic differentiation of C2C12 cells.
Doxycycline (Doxy) treatment protected the myogenic capacity of myoblasts from IL-17 inhibition and, moreover, increased myotubes hypertrophy.
Doxy blocked the capacity of IL-17 to stimulate MMP-9 production by regulating IL-17-induced ERK1/2 MAPK activation.
Our results imply that MMP-9 mediates IL-17’s capacity to inhibit myoblast differentiation during inflammatory diseases and indicate that Doxy can modulate myoblast response to inflammatory induction by IL-17.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Obradović, Hristina& Krstić, Jelena& Kukolj, Tamara& Trivanović, Drenka& Đorđević, Ivana Okić& Mojsilović, Slavko…[et al.]. 2016. Doxycycline Inhibits IL-17-Stimulated MMP-9 Expression by Downregulating ERK12 Activation: Implications in Myogenic Differentiation. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1110986
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Obradović, Hristina…[et al.]. Doxycycline Inhibits IL-17-Stimulated MMP-9 Expression by Downregulating ERK12 Activation: Implications in Myogenic Differentiation. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1110986
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Obradović, Hristina& Krstić, Jelena& Kukolj, Tamara& Trivanović, Drenka& Đorđević, Ivana Okić& Mojsilović, Slavko…[et al.]. Doxycycline Inhibits IL-17-Stimulated MMP-9 Expression by Downregulating ERK12 Activation: Implications in Myogenic Differentiation. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1110986
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110986
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر