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Correlation of Surface Toll-Like Receptor 9 Expression with IL-17 Production in Neutrophils during Septic Peritonitis in Mice Induced by E. coli
المؤلفون المشاركون
Ren, Yunjia
Hua, Li
Meng, Xiuping
Xiao, Yue
Hao, Xu
Guo, Sheng
Zhao, Peiyan
Wang, Luowei
Dong, Boqi
Yu, Yongli
Wang, Liying
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-25
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
IL-17 is a proinflammatory cytokine produced by various immune cells.
Polymorphonuclear neutrophils (PMNs) are the first line of defense in bacterial infection and express surface Toll-like receptor 9 (sTLR9).
To study the relationship of sTLR9 and IL-17 in PMNs during bacterial infection, we infected mice with E.
coli intraperitoneally to establish a septic peritonitis model for studying the PMNs response in peritoneal cavity.
We found that PMNs and some of “giant cells” were massively accumulated in the peritoneal cavity of mice with fatal septic peritonitis induced by E.
coli.
Kinetically, the CD11b+ PMNs were increased from 20–40% at 18 hours to >80% at 72 hours after infection.
After E.
coli infection, sTLR9 expression on CD11b+ and CD11b− PMNs and macrophages in the PLCs were increased at early stage and deceased at late stage; IL-17 expression was also increased in CD11b+ PMNs, CD11b− PMNs, macrophages, and CD3+ T cells.
Using experiments of in vitro blockage, qRT-PCR and cell sorting, we confirmed that PMNs in the PLCs did increase their IL-17 expression during E.
coli infection.
Interestingly, sTLR9−CD11b+Ly6G+ PMNs, not sTLR9+CD11b+Ly6G+ PMNs, were found to be able to increase their IL-17 expression.
Together, the data may help understand novel roles of PMNs in septic peritonitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ren, Yunjia& Hua, Li& Meng, Xiuping& Xiao, Yue& Hao, Xu& Guo, Sheng…[et al.]. 2016. Correlation of Surface Toll-Like Receptor 9 Expression with IL-17 Production in Neutrophils during Septic Peritonitis in Mice Induced by E. coli. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1111008
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ren, Yunjia…[et al.]. Correlation of Surface Toll-Like Receptor 9 Expression with IL-17 Production in Neutrophils during Septic Peritonitis in Mice Induced by E. coli. Mediators of Inflammation No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1111008
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ren, Yunjia& Hua, Li& Meng, Xiuping& Xiao, Yue& Hao, Xu& Guo, Sheng…[et al.]. Correlation of Surface Toll-Like Receptor 9 Expression with IL-17 Production in Neutrophils during Septic Peritonitis in Mice Induced by E. coli. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1111008
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111008
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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