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Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress
المؤلفون المشاركون
Shim, Insop
Park, Sun Kyu
Starkweather, Angela
Lee, Hyun-ju
An, Kyungeh
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
It has been demonstrated that immobilization (IMO) stress affects neuroimmune systems followed by alterations of physiology and behavior.
Interleukin-4 (IL-4), an anti-inflammatory cytokine, is known to regulate inflammation caused by immune challenge but the effect of IMO on modulation of IL-4 expression in the brain has not been assessed yet.
Here, it was demonstrated that IL-4 was produced by noradrenergic neurons in the locus coeruleus (LC) of the brain and release of IL-4 was reduced in response to IMO.
It was observed that IMO groups were more anxious than nontreated groups.
Acute IMO (2 h/day, once) stimulated secretion of plasma corticosterone and tyrosine hydroxylase (TH) in the LC whereas these increments were diminished in exposure to chronic stress (2 h/day, 21 consecutive days).
Glucocorticoid receptor (GR), TH, and IL-4-expressing cells were localized in identical neurons of the LC, indicating that hypothalamic-pituitary-adrenal- (HPA-) axis and sympathetic-adrenal-medullary- (SAM-) axis might be involved in IL-4 secretion in the stress response.
Accordingly, it was concluded that stress-induced decline of IL-4 concentration from LC neurons may be related to anxiety-like behavior and an inverse relationship exists between IL-4 secretion and HPA/SAM-axes activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Hyun-ju& Park, Sun Kyu& Starkweather, Angela& An, Kyungeh& Shim, Insop. 2016. Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111015
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Hyun-ju…[et al.]. Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111015
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Hyun-ju& Park, Sun Kyu& Starkweather, Angela& An, Kyungeh& Shim, Insop. Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111015
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111015
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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