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Mesenchymal Stem Cell-Educated Macrophages Ameliorate LPS-Induced Systemic Response
المؤلفون المشاركون
Shu, Qiang
Cheng, Baoli
Zheng, Guoping
Ge, Menghua
Qiu, Guanguan
Xu, Jianguo
Tao, Huikang
Huang, Lanfang
Chen, Lina
Lai, Dengming
Hu, Yao-Qin
Qin, Chao-Jin
Zhang, Yan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Both bone marrow and adipose-derived mesenchymal stem cells (ASCs) have immunomodulatory effects.
The goal of this study was to determine whether ASCs-educated macrophages could directly ameliorate LPS-induced systemic response in a mouse model.
Mouse peritoneal macrophages were cocultured with ASCs in a Transwell system for 2 days to educate macrophages.
Mice were divided into 5 groups: control, LPS, LPS + ASCs, LPS + untreated macrophages, and LPS + educated macrophages.
Educated macrophages decreased lung inflammation, weight loss, pulmonary edema, and inflammatory cytokine response.
In vitro, ASCs increased expression of M2 macrophages independent of direct cell-to-cell contact when macrophages were treated with LPS or serum from patients with acute respiratory distress syndrome (ARDS).
When macrophages were cultured with serum from ARDS patients who were treated with ASCs or placebo in our previous clinical trial, there was no difference in M2 macrophage levels before and after ASCs treatment indicating a suboptimal response to the treatment protocol.
ASCs also reduced the levels of LPS-induced proinflammatory cytokines in vitro which were mimicked by IL-10 and blocked by antibodies for IL-10 and IL-10 receptor supporting the notion that educated macrophages exert their anti-inflammatory effects via IL-10-dependent mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Yao-Qin& Qin, Chao-Jin& Zheng, Guoping& Lai, Dengming& Tao, Huikang& Zhang, Yan…[et al.]. 2016. Mesenchymal Stem Cell-Educated Macrophages Ameliorate LPS-Induced Systemic Response. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111030
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Yao-Qin…[et al.]. Mesenchymal Stem Cell-Educated Macrophages Ameliorate LPS-Induced Systemic Response. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1111030
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Yao-Qin& Qin, Chao-Jin& Zheng, Guoping& Lai, Dengming& Tao, Huikang& Zhang, Yan…[et al.]. Mesenchymal Stem Cell-Educated Macrophages Ameliorate LPS-Induced Systemic Response. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111030
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111030
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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