![](/images/graphics-bg.png)
The Regulatory Role of Rolipram on Inflammatory Mediators and CholinergicAdrenergic Stimulation-Induced Signals in Isolated Primary Mouse Submandibular Gland Cells
المؤلفون المشاركون
Hong, Jeong Hee
Lee, Dong Un
Shin, Dong Min
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Exposure to bacterial lipopolysaccharides (LPS) induces inflammatory signals in salivary glands.
We investigated the regulatory role of phosphodiesterase 4 (PDE4) inhibitor rolipram on inflammatory mediators and cholinergic/adrenergic stimulation-induced intracellular Ca2+ signaling in salivary acinar and ductal cells.
Submandibular gland (SMG) expressed PDE4A through 4D mRNA and PDE4 was localized in the luminal membrane of SMG.
LPS induced Ca2+ signaling and ROS production in SMG.
Treatment with rolipram blocked LPS-induced Ca2+ increase and ROS production.
The application of histamine evoked Ca2+ signals and ROS production, which were attenuated by rolipram in SMG cells.
Moreover, LPS-induced NLRP3 inflammasome and cleaved caspase-1 were inhibited by rolipram.
The inhibitory role of rolipram in ROS-induced Ca2+ signaling was mainly observed in acinar cells and not in ductal cells.
Rolipram also protected SMG acinar but not ductal cells from LPS-induced cell membrane damage.
In the case of cholinergic/adrenergic stimulation, carbachol/isoproterenol-induced Ca2+ signals were upregulated by the treatment of rolipram in SMG.
In the case of cAMP-dependent ductal bicarbonate secretion by rolipram, no effect was observed on the modulation of ductal chloride/bicarbonate exchange activity.
Rolipram could suppress the inflammatory signals and could be a potential therapeutic strategy against LPS-induced inflammation to protect the salivary gland cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Dong Un& Shin, Dong Min& Hong, Jeong Hee. 2016. The Regulatory Role of Rolipram on Inflammatory Mediators and CholinergicAdrenergic Stimulation-Induced Signals in Isolated Primary Mouse Submandibular Gland Cells. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111031
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Dong Un…[et al.]. The Regulatory Role of Rolipram on Inflammatory Mediators and CholinergicAdrenergic Stimulation-Induced Signals in Isolated Primary Mouse Submandibular Gland Cells. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111031
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Dong Un& Shin, Dong Min& Hong, Jeong Hee. The Regulatory Role of Rolipram on Inflammatory Mediators and CholinergicAdrenergic Stimulation-Induced Signals in Isolated Primary Mouse Submandibular Gland Cells. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111031
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111031
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)