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MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations
المؤلفون المشاركون
Volk, Hans-Dieter
Tsaousi, Athanasia
Witte, Ellen
Witte, Katrin
Röwert-Huber, Hans-Joachim
Sterry, Wolfram
Wolk, Kerstin
Schneider-Burrus, Sylke
Sabat, Robert
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites.
It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated with metabolic alterations.
Here, we demonstrate that one of the most highly upregulated molecules in AI lesions is matrix metalloproteinase 8 (MMP8), an enzyme specialized in the degradation of extracellular matrix components and the HDL component apolipoprotein A-I.
Granulocytes, which were present in AI lesions, secreted high amounts of MMP8 especially after TNF-α stimulation.
Furthermore, activated fibroblasts but not keratinocytes were found to express MMP8.
The high lesional MMP8 levels were accompanied by elevated blood levels that positively correlated with TNF-α blood levels and disease severity assessed by Sartorius score, especially with the number of regions with inflammatory nodules/abscesses and fistulas.
Additionally, we found a negative correlation between blood MMP8 and HDL-cholesterol levels, suggesting a contributory role of MMP8 in metabolic alterations in AI.
In summary, we demonstrate elevated MMP8 levels in AI lesions, suggest their role in skin destruction and metabolic alterations, and recommend the use of MMP8 as blood biomarker for AI disease activity assessment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tsaousi, Athanasia& Witte, Ellen& Witte, Katrin& Röwert-Huber, Hans-Joachim& Volk, Hans-Dieter& Sterry, Wolfram…[et al.]. 2016. MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111051
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tsaousi, Athanasia…[et al.]. MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111051
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tsaousi, Athanasia& Witte, Ellen& Witte, Katrin& Röwert-Huber, Hans-Joachim& Volk, Hans-Dieter& Sterry, Wolfram…[et al.]. MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111051
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111051
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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