Parallel Aspects of the Microenvironment in Cancer and Autoimmune Disease
المؤلفون المشاركون
Rahat, Michal Amit
Shakya, Jivan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-22
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Cancer and autoimmune diseases are fundamentally different pathological conditions.
In cancer, the immune response is suppressed and unable to eradicate the transformed self-cells, while in autoimmune diseases it is hyperactivated against a self-antigen, leading to tissue injury.
Yet, mechanistically, similarities in the triggering of the immune responses can be observed.
In this review, we highlight some parallel aspects of the microenvironment in cancer and autoimmune diseases, especially hypoxia, and the role of macrophages, neutrophils, and their interaction.
Macrophages, owing to their plastic mode of activation, can generate a pro- or antitumoral microenvironment.
Similarly, in autoimmune diseases, macrophages tip the Th1/Th2 balance via various effector cytokines.
The contribution of neutrophils, an additional plastic innate immune cell population, to the microenvironment and disease progression is recently gaining more prominence in both cancer and autoimmune diseases, as they can secrete cytokines, chemokines, and reactive oxygen species (ROS), as well as acquire an enhanced ability to produce neutrophil extracellular traps (NETs) that are now considered important initiators of autoimmune diseases.
Understanding the contribution of macrophages and neutrophils to the cancerous or autoimmune microenvironment, as well as the role their interaction and cooperation play, may help identify new targets and improve therapeutic strategies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rahat, Michal Amit& Shakya, Jivan. 2016. Parallel Aspects of the Microenvironment in Cancer and Autoimmune Disease. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1111064
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rahat, Michal Amit& Shakya, Jivan. Parallel Aspects of the Microenvironment in Cancer and Autoimmune Disease. Mediators of Inflammation No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1111064
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rahat, Michal Amit& Shakya, Jivan. Parallel Aspects of the Microenvironment in Cancer and Autoimmune Disease. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1111064
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111064
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر