Kinin Peptides Enhance Inflammatory and Oxidative Responses Promoting Apoptosis in a Parkinson’s Disease Cellular Model
المؤلفون المشاركون
Niewiarowska-Sendo, Anna
Kozik, Andrzej
Guevara-Lora, Ibeth
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-18
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Kinin peptides ubiquitously occur in nervous tissue and participate in inflammatory processes associated with distinct neurological disorders.
These substances have also been demonstrated to promote the oxidative stress.
On the other hand, the importance of oxidative stress and inflammation has been emphasized in disorders that involve the neurodegenerative processes such as Parkinson’s disease (PD).
A growing number of reports have demonstrated the increased expression of kinin receptors in neurodegenerative diseases.
In this study, the effect of bradykinin and des-Arg10-kallidin, two representative kinin peptides, was analyzed with respect to inflammatory response and induction of oxidative stress in a PD cellular model, obtained after stimulation of differentiated SK-N-SH cells with a neurotoxin, 1-methyl-4-phenylpyridinium.
Kinin peptides caused an increased cytokine release and enhanced production of reactive oxygen species and NO by cells.
These changes were accompanied by a loss of cell viability and a greater activation of caspases involved in apoptosis progression.
Moreover, the neurotoxin and kinin peptides altered the dopamine receptor 2 expression.
Kinin receptor expression was also changed by the neurotoxin.
These results suggest a mediatory role of kinin peptides in the development of neurodegeneration and may offer new possibilities for its regulation by using specific antagonists of kinin receptors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Niewiarowska-Sendo, Anna& Kozik, Andrzej& Guevara-Lora, Ibeth. 2016. Kinin Peptides Enhance Inflammatory and Oxidative Responses Promoting Apoptosis in a Parkinson’s Disease Cellular Model. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1111069
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Niewiarowska-Sendo, Anna…[et al.]. Kinin Peptides Enhance Inflammatory and Oxidative Responses Promoting Apoptosis in a Parkinson’s Disease Cellular Model. Mediators of Inflammation No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1111069
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Niewiarowska-Sendo, Anna& Kozik, Andrzej& Guevara-Lora, Ibeth. Kinin Peptides Enhance Inflammatory and Oxidative Responses Promoting Apoptosis in a Parkinson’s Disease Cellular Model. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1111069
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111069
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر