Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism
المؤلفون المشاركون
He, Shaoheng
Chen, Huifang
Wang, Junling
Xu, Chiyan
Liu, Xin
Zhan, Mengmeng
Chen, Hanqiu
Fang, Zeman
Zhang, Huiyun
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Mast cells are primary effector cells of allergy, and recruitment of mast cells in involved tissue is one of the key events in allergic inflammation.
Tryptase is the most abundant secretory product of mast cells, but little is known of its influence on mast cell accumulation.
Using mouse peritoneal model, cell migration assay, and flow cytometry analysis, we investigated role of tryptase in recruiting mast cells.
The results showed that tryptase induced up to 6.7-fold increase in mast cell numbers in mouse peritoneum following injection.
Inhibitors of tryptase, an antagonist of PAR-2 FSLLRY-NH2, and pretreatment of mice with anti-ICAM-1, anti-CD11a, and anti-CD18 antibodies dramatically diminished tryptase induced mast cell accumulation.
On the other hand, PAR-2 agonist peptides SLIGRL-NH2 and tc-LIGRLO-NH2 provoked mast cell accumulation following injection.
These implicate that tryptase induced mast cell accumulation is dependent on its enzymatic activity, activation of PAR-2, and interaction between ICAM-1 and LFA-1.
Moreover, induction of trans-endothelium migration of mast cells in vitro indicates that tryptase acts as a chemoattractant.
In conclusion, provocation of mast cell accumulation by mast cell tryptase suggests a novel self-amplification mechanism of mast cell accumulation.
Mast cell stabilizers as well as PAR-2 antagonist agents may be useful for treatment of allergic reactions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Xin& Wang, Junling& Zhang, Huiyun& Zhan, Mengmeng& Chen, Hanqiu& Fang, Zeman…[et al.]. 2016. Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111155
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Xin…[et al.]. Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111155
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Xin& Wang, Junling& Zhang, Huiyun& Zhan, Mengmeng& Chen, Hanqiu& Fang, Zeman…[et al.]. Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111155
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111155
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر