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12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis
المؤلفون المشاركون
Wens, Inez
O Eijnde, Bert
Nuyts, Amber H.
Hens, Niel
Koppen, Gudrun
Goossens, Herman
Van Damme, Pierre
De Winter, Benedicte
Deckx, Nathalie
Cools, Nathalie
Berneman, Zwi N.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-20
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Previously, we reported that patients with multiple sclerosis (MS) demonstrate improved muscle strength, exercise tolerance, and lean tissue mass following a combined endurance and resistance exercise program.
However, the effect of exercise on the underlying disease pathogenesis remains elusive.
Since recent evidence supports a crucial role of dendritic cells (DC) in the pathogenesis of MS, we investigated the effect of a 12-week combined exercise program in MS patients on the number and function of DC.
We demonstrate an increased number of plasmacytoid DC (pDC) following the exercise program.
These pDC display an activated phenotype, as evidenced by increased numbers of circulating CD62L+ and CD80+ pDC.
Interestingly, the number of CD80+ pDC positively correlates with the presence of IL-10-producing regulatory type 1 cells (Tr1), an important cell type for maintaining peripheral tolerance to self-antigens.
In addition, decreased production of the inflammatory mediators, TNF-α and MMP-9, upon Toll-like receptor (TLR) stimulation was found at the end of the exercise program.
Overall, our findings suggest that the 12-week exercise program reduces the secretion of inflammatory mediators upon TLR stimulation and promotes the immunoregulatory function of circulating pDC, suggestive for a favorable impact of exercise on the underlying immunopathogenesis of MS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deckx, Nathalie& Wens, Inez& Nuyts, Amber H.& Hens, Niel& De Winter, Benedicte& Koppen, Gudrun…[et al.]. 2016. 12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111168
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deckx, Nathalie…[et al.]. 12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis. Mediators of Inflammation No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1111168
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deckx, Nathalie& Wens, Inez& Nuyts, Amber H.& Hens, Niel& De Winter, Benedicte& Koppen, Gudrun…[et al.]. 12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111168
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111168
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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