The Th17Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population
المؤلفون المشاركون
Wei, Wei
He, Xiaojuan
Zhao, Ning
Gong, Yang
Lu, Aiping
Lin, Yifan
Jiang, Miao
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population.
Methods.
Ninety UC patients and 30 healthy subjects were enrolled.
The serum IL-17 and TGF-β1 levels of these participants were measured with ELISA; the percentage of Th17 and Treg cells in peripheral blood was determined with flow cytometry.
Results.
In UC patients, the levels of IL-17 and Th17 were significantly higher compared with healthy subjects; the percentage of Th17 and IL-17 level in moderate and severe subgroup was significantly higher than in mild subgroup; a positive correlation existed between these two indexes and clinical activity index and endoscopic evaluation.
TGF-β1 level and Treg cells in UC patients were lower than healthy subjects.
TGF-β1 level in moderate and severe subgroup was lower than in mild subgroup.
There was a negative linear correlation between Treg cells and clinical activity index, endoscopic evaluation.
A positive correlation was detected between Treg cells and TGF-β1 level.
Conclusions.
Th17/Treg immune imbalance might play a crucial role in the development of UC.
To induce the production of Treg cells and TGF-β1, inhibit the level of Th17 and IL-17, and thus recover the Th17/Treg immune balance might imply new therapeutic targets in UC management.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gong, Yang& Lin, Yifan& Zhao, Ning& He, Xiaojuan& Lu, Aiping& Wei, Wei…[et al.]. 2016. The Th17Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1111196
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gong, Yang…[et al.]. The Th17Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population. Mediators of Inflammation No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1111196
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gong, Yang& Lin, Yifan& Zhao, Ning& He, Xiaojuan& Lu, Aiping& Wei, Wei…[et al.]. The Th17Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1111196
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111196
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر