Neuropilin-1highCD4+CD25+ Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis
المؤلفون المشاركون
Liu, Yan-Cun
Chai, Yan-Fen
Gao, Yu-Lei
Qi, An-Long
Yao, Ying
Dong, Ning
Wang, Li-Jun
Yao, Yong-Ming
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Regulatory T cells (Tregs) appear to be involved in sepsis-induced immune dysfunction; neuropilin-1 (Nrp-1) was identified as a surface marker for C D 4 + C D 25 + Tregs.
In the current study, we investigated the negative immunoregulation of N r p - 1 h i g h C D 4 + C D 25 + Tregs and the potential therapeutic value of Nrp-1 in sepsis.
Splenic C D 4 + C D 25 + Tregs from cecal ligation and puncture (CLP) mouse models were further segregated into N r p - 1 h i g h Tregs and N r p - 1 l o w Tregs; they were cocultured with CD4+CD25− T cells.
The expression of forkhead/winged helix transcription factor-3 (Foxp-3), cytotoxic T-lymphocyte associated antigen-4 (CTLA-4), membrane associated transforming growth factor-β (TGF- β m + ), apoptotic rate, and secretive ability [including TGF-β and interleukin-10 (IL-10)] for various types of Tregs, as well as the immunosuppressive ability of Tregs on CD4+CD25− T cells, were determined.
Meanwhile, the impact of recombinant Nrp-1 polyclonal antibody on the demethylation of Foxp-3-TSDR (Treg-specific demethylated region) was measured in in vitro study.
Sepsis per se markedly promoted the expression of Nrp-1 of C D 4 + C D 25 + Tregs.
Foxp-3/CTLA-4/TGF- β m + of N r p - 1 h i g h Tregs were upregulated by septic challenge.
N r p - 1 h i g h Tregs showed strong resilience to apoptosis and secretive ability and the strongest immunosuppressive ability on CD4+CD25− T cells.
In the presence of lipopolysaccharide (LPS), the recombinant Nrp-1 polyclonal antibody reduced the demethylation of Foxp-3-TSDR.
N r p - 1 h i g h Tregs might reveal primary negative immunoregulation in sepsis; Nrp-1 could represent a new potential therapeutic target for the study of immune regulation in sepsis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Yu-Lei& Chai, Yan-Fen& Qi, An-Long& Yao, Ying& Liu, Yan-Cun& Dong, Ning…[et al.]. 2016. Neuropilin-1highCD4+CD25+ Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111197
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Yu-Lei…[et al.]. Neuropilin-1highCD4+CD25+ Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111197
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Yu-Lei& Chai, Yan-Fen& Qi, An-Long& Yao, Ying& Liu, Yan-Cun& Dong, Ning…[et al.]. Neuropilin-1highCD4+CD25+ Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111197
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111197
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر